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TTD Drug ID: DAP000912

Drug Information
NameCilazapril
Synonyms(1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid 9-ethyl ester monohydrate; MolPort-003-986-212; Cilazaprilum [Latin]; Inibace; 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, octahydro-9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-10-oxo-, hydrate, (1S-(1-alpha,9-alpha(R*)))-; D07699; Cilazapril (anhydrous); 92077-78-6; CID56330; MolPort-005-943-746; C22H31N3O5; 88768-40-5; Dynorm; Cilazapril anhydrous; LS-129694; D01069; Inhibace (TN); (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid hydrate; Ro-31-2848; Ro 31-2848 monohydrate; Ro 31-2848; AC-269; Cilazapril hydrate; AC1L1KU0; AC1L1KTX; 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, monohydrate, (1S-(1alpha,9alpha(R*)))-; (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid; Cilazapril [USAN:INN:BAN:JAN]; UNII-8Q9454114Q; Cilazapril (USAN); 92077-78-6 (Parent); 88768-40-5 (anhydrous); Ro 34-2848; Cilazapril hydrate (JAN); LS-178061; CHEMBL515606; Justor; Cilazaprilum; Inhibace; I06-1280; DB01340; cilazapril; CILAZAPRIL MONOHYDRATE; TL8000244; Cilazapril (INN); Ro-312848; AC1Q63IB; Cilazil; UNII-19KW7PI29F; Cilazapril, Anhydrous; CID56329; Vascace; 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-(((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, (1S,9S)-; 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, (1S-(1alpha,9alpha(R*)))-; I06-1285
IndicationCongestive heart failure
[ICD9: 428.0   ICD10: I50]
Approved    [1]
Structure

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InChI1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-1
4-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,
10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1
InChIKeyHHHKFGXWKKUNCY-FHWLQOOXSA-N
Canonical SMILESCCOC(=O)C(CCC1=CC=CC=C1)NC2CCCN3CCCC(N3C2=O)C(=O)O    
Isomeric SMILESCCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCCN3CCC[C@H](N3C2=O)C(=O)O
Therapeutic ClassAntihypertensive Agents
CAS NumberCAS 92077-78-6
FormulaC22H33N3O6
PubChem Compound IDCID 56330.
PubChem Substance IDSID 206709.
SuperDrug ATC IDC09AA08
SuperDrug CAS ID092077786;
TargetAngiotensin-converting enzymeInhibitor[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial. Am J Kidney Dis. 2008 Sep;52(3):486-93. Epub 2008 Apr 18. To Reference



 

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