TTD Drug ID: DAP000913

Drug Information
Name	Masoprocol
Synonyms	741285-10-9; meso-NDGA; NCGC00094201-01; NDGA; C18H22O4; EU-0100877; 4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol; AC1Q7ACC; AC1L2G35; 27686-84-6; DB00179; (R*,S*)-4,4'-(2,3-Dimethylbutane-1,4-diyl)bispyrocatechol; 334707-72-1; 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (R*,S*)-; meso-4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol; 1,2-Benzenediol, 4,4'-((2R,3S)-2,3-dimethyl-1,4-butanediyl)bis-, rel-; EINECS 248-606-6; D04862; CHX-100; 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (R*,S*)-; Masoprocol (USAN/INN); NCGC00094201-04; ZINC00012342; CID71398; Nordihydroguaiaretic acid (meso-form); ZINC12359927; Actinex (TN); Lopac0_000877; Lopac-N-5023; C10719; 500-38-9; BIDD:ER0127; Masoprocolum [INN-Latin]; NCGC00015741-03; NCGC00094201-02; TNP00263; Actinex; UNII-7BO8G1BYQU; CHX 100; NCGC00015741-02; Masoprocolum; meso-Nordihydroguaiaretic acid; meso-4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol; Nordihydroguaiaretic acid from Larrea divaricata (creosote bush); LS-174190; Masoprocol; CHEMBL313972; Masoprocol [USAN:INN]; N 5023; NCGC00015741-01
Indication	Prostate cancer [ICD9: 185   ICD10: C61]			Approved    [1]
Structure	Click to save drug structure in 3D MOL format Click to save drug structure in 2D MOL format
InChI	1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)1 8(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
InChIKey	HCZKYJDFEPMADG-TXEJJXNPSA-N
Canonical SMILES	CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O
Isomeric SMILES	C[C@H](CC1=CC(=C(C=C1)O)O)[C@@H](C)CC2=CC(=C(C=C2)O)O
Therapeutic Class	Antineoplastic Agents
CAS Number	CAS 500-38-9
Formula	C18H22O4
PubChem Compound ID	CID 71398.
PubChem Substance ID	SID 12902.
SuperDrug ATC ID	L01XX10
SuperDrug CAS ID	027686846;
Target	Arachidonate 5-lipoxygenase			Inhibitor	[2]
Ref 1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2	Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E593-600. To Reference

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