Therapeutic Targets Database
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TTD Drug ID: DAP000933

Drug Information
NameEszopiclone
SynonymsCHEBI:53760; NCGC00159515-02; AC1LJ6QN; SEP-0227018; SEP-225441; (+)-Zopiclone; Lunesta; (+)-(5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate; 1-Piperazinecarboxylic acid, 4-methyl-, (5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester; D02624; CID969472; SEP-190; MolPort-003-666-599; 138729-47-2; KS-1055; CHEMBL1522; AC1Q3ZTD; UNII-UZX80K71OE; CPD000550478; HSDB 7472; Estorra; Lunivia; DB00402; ZINC19632834; ( )-Zopiclone; MLS001165744; Eszopiclone; MolPort-002-885-823; Eszopiclone (JAN/USAN/INN); Lunesta (TN); AC-5546; Eszopiclone [USAN:INN]; (plus)-Zopiclone; (S)-Zopiclone; SMR000550478; LS-186538; (5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate; [(7S)-6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate; LS-187790; Estorra (TN); Esopiclone; LS-187032; (5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate; SAM002548982; (5S)-6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate; SEP-0227108; SPECTRUM1505188
Trade NameLunesta
CompanyGSK
IndicationInsomnia
[ICD9: 307.41, 307.42, 327.0, 780.51, 780.52   ICD10: F51.0, G47.0]
Approved    [1]
Structure

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InChI1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-1
4)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3/t16-/m0
/s1
InChIKeyGBBSUAFBMRNDJC-INIZCTEOSA-N
Canonical SMILESCN1CCN(CC1)C(=O)OC2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl    
Isomeric SMILESCN1CCN(CC1)C(=O)O[C@H]2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl
Therapeutic ClassHypnotics and Sedatives
CAS NumberCAS 138729-47-2
FormulaC17H17ClN6O3
PubChem Compound IDCID 969472.
PubChem Substance IDSID 734464.
SuperDrug ATC IDN05CF04
N05CF04
TargetBenzodiazepine receptorAgonist[2][3]
Ref 1Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62. To Reference
Ref 2New hypnotics: perspectives from sleep physiology. Vertex. 2007 Jul-Aug;18(74):294-9. To Reference
Ref 3Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. To Reference



 

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