Therapeutic Targets Database
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TTD Drug ID: DAP000938

Drug Information
NamePenbutolol
SynonymsC18H29NO2; Levatolol; CCRIS 2855; (-)-Penbutolol; Betapressin; DB01359; Penbutolol [INN:BAN]; HOE 893d; Paginol; PENBUTOLOL SULFATE; 38363-32-5 (sulfate (2:1) salt); AC1Q59G2; 1-(tert-Butylamino)-3-(o-cyclopentylphenoxy)propan-2-ol; Penbutolol Sulfate (2:1); l-Penbutolol; Levatol; penbutolol; 2-Propanol, 1-(2-cyclopentylphenoxy)-3-((1,1-dimethylethyl)amino)-; BRN 4484348; CHEMBL1290; PDSP1_000056; CID37464; (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol; CHEMBL87418; C07416; UNII-78W62V43DY; Penbutololum; Levopenbutol; 2-Propanol, 1-(2-cyclopentylphenoxy)-3-((1,1-dimethylethyl)amino)-, (S)-; Penbutololum [INN-Latin]; AC1L1XS5; Penbutolol (INN); LS-122000; 61914-98-5; LS-174602; Lobeta; D08074; PDSP2_000056; HOE 893; EINECS 253-074-3; 38363-40-5; S(-)-Penbutolol
Trade NameLevatol; Levatolol; Lobeta; Paginol; Hostabloc; Betapressin
IndicationHypertension
[ICD9: 401   ICD10: I10, I11, I12, I13, I15]
Approved    [1]
Structure

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InChI1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-
4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m0/s1
InChIKeyKQXKVJAGOJTNJS-HNNXBMFYSA-N
Canonical SMILESCC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O    
Isomeric SMILESCC(C)(C)NC[C@@H](COC1=CC=CC=C1C2CCCC2)O
Therapeutic ClassAntihypertensive Agents
CAS NumberCAS 36507-48-9
FormulaC18H29NO2
PubChem Compound IDCID 37464.
PubChem Substance IDSID 9620.
SuperDrug ATC IDC07AA23
SuperDrug CAS ID036507489;
TargetBeta adrenergic receptorAntagonist[2][3]
Ref 1Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism. J Clin Pharmacol. 1990 May;30(5):412-21. To Reference
Ref 2beta-Adrenergic receptor blockers--a group of chiral drugs: different effects of each enantiomer. Ceska Slov Farm. 2002 May;51(3):121-8. To Reference
Ref 3Decrease in penbutolol central response as a cause of changes in its serum protein binding. J Pharm Pharmacol. 1990 Mar;42(3):164-6. To Reference



 

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