Therapeutic Targets Database
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TTD Drug ID: DAP000987

Drug Information
NameTemozolomide
SynonymsTemozolamide; CHEBI:153686; SMR000466338; 8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one; Temozolomidum [Latin]; LS-80558; TMZ-Bioshuttle; AC1L1K9B; 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide; {Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide,} 3, 4-dihydro-3-methyl-4-oxo-; M&B-39831; CPD000466338; ZINC01482184; CHEMBL810; NCI60_003316; Sch-52365; 85622-93-1; HMS2090B08; NSC-362856; NSC362856; Temozolomide [INN:BAN]; C047246; temozolomide; CCRG-81045; Bio-0147; MB 39831; 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; M&B 39831; NSC 362856; NCGC00167429-02; 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide; Schering brand of temozolomide; Temozolomidum; D06067; CCRIS 8996; Temodal; I14-1943; MLS002701861; 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; M-39831; DB00853; Temodal (TN); Schering-Plough brand of temozolomide; UNII-YF1K15M17Y; TL8005593; Imidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxo-; Essex brand of temozolomide; 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide; Sch 52365; Methazolastone; C6H6N6O2; M B 39831; Temozolomide (JAN/USAN/INN); I06-0149; Temozolodida; HMS2051O12; Temozolodida [Spanish]; Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxo-; 3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide; AC-758; SAM001246636; MLS001424028; STK623541; Temodar; BRN 5547136; CID5394; CCRG 81045; NCGC00167429-01; M & B 39831; MLS000759447; BIDD:GT0204
Trade NameTemodar; Temodal
CompanySchering-Plough
IndicationGrade IV astrocytoma
[ICD9: 191   ICD10: C71]
Approved    [1]
Structure

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InChI1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7
,13)
InChIKeyBPEGJWRSRHCHSN-UHFFFAOYSA-N
Canonical SMILESCN1C(=O)N2C=NC(=C2N=N1)C(=O)N    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 85622-93-1
FormulaC6H6N6O2
PubChem Compound IDCID 5394.
PubChem Substance IDSID 225666.
SuperDrug ATC IDL01AX03
SuperDrug CAS ID085622931;
TargetDNABreaker[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2DNA ligase IV as a new molecular target for temozolomide. Biochem Biophys Res Commun. 2009 Jul 15. [Epub ahead of print] To Reference



 

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