Therapeutic Targets Database
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TTD Drug ID: DAP001012

Drug Information
NameChlorotrianisene
SynonymsHMS1570G16; Spectrum4_000954; MolPort-001-783-515; Merbentul; Chlorestrolo; Clorotrianisene; Chlorotrianisene [INN:BAN]; SMR000058658; CID11289; Prestwick2_000757; NSC10108; HSDB 3302; Metace; Spectrum2_000704; BSPBio_002005; Chlorotrianisene [BAN:INN]; 1,1',1''-(2-chloroethene-1,1,2-triyl)tris[4-(methyloxy)benzene]; KBio2_000596; Benzene, 1,1',1'-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy)-; AC-12512; Tris(p-methoxyphenyl)chloroethylene; Clorotrianiseno [INN-Spanish]; Clorotrianiseno; Clorotrisin; Triagen; Khlortrianizen; D00269; chlorotrianisene; Chlortrianizen; WLN: 1OR DYGUYR DO1&R DO1; Spectrum5_000711; Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy-; CHEBI:3641; KBio2_005732; AC1L1X1E; Prestwick1_000757; CAS-569-57-3; 4-06-00-07650 (Beilstein Handbook Reference); SPBio_002713; Anisene; Chlorotrianisene (INN); SPBio_000887; Spectrum_000136; NSC-10108; Chlorotrianisene [Nonsteroidal oestrogens]; Tace (pharmaceutical); Clorotrianisene [DCIT]; Spectrum3_000343; 1,1',1''-(1-Chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene); TACE (TN); TACE; Chlorotrianisine; SPECTRUM1500181; Chloortrianisestrol; Chlorotrianisenum; NCGC00091333-03; Prestwick3_000757; KBioGR_001568; MLS002415722; KBio2_003164; Chlorotrisin; NCGC00016511-01; Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy)-; NCGC00091333-02; Chlorotris(p-methoxyphenyl)ethylene; Chlortrianisestrol; C23H21ClO3; 1-[1-chloro-2,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene; Rianil; Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy-; C7128_SIGMA; KBio3_001225; chlorotrianisestrol; Tace-fn; Tri-p-anisylchloroethylene; Prestwick0_000757; HMS2091C20; Clorestrolo; Hormonisene; Prestwick_22; MLS000028625; CCRIS 4769; BRN 1891845; NCGC00091333-01; LS-226; ZINC01530598; AC1Q3FDW; BSPBio_000774; Chlorotrianisenum [INN-Latin]; Chlortrianisenum; Chlortrianisen; AB00051941; Chlortrianisene; Chlorotrianizen; UNII-6V5034L121; MolPort-005-933-845; Chlortrianisoestrolum; DB00269; KBioSS_000596; Ethylene, chlorotris(p-methoxyphenyl)-; HMS1920K17; CHEMBL1200761; Trianisestrol; EINECS 209-318-6; 569-57-3; BPBio1_000852; 1,1',1''-(2-chloroethene-1,1,2-triyl)tris(4-methoxybenzene)
IndicationMenopause
[ICD9: 627.2   ICD10: N95.0]
Approved    [1]
Structure

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InChI1S/C23H21ClO3/c1-25-19-10-4-16(5-11-19)22(17-6-12-20(26-2)13-7-17
)23(24)18-8-14-21(27-3)15-9-18/h4-15H,1-3H3
InChIKeyBFPSDSIWYFKGBC-UHFFFAOYSA-N
Canonical SMILESCOC1=CC=C(C=C1)C(=C(C2=CC=C(C=C2)OC)Cl)C3=CC=C(C=C3)OC    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 569-57-3
FormulaC23H21ClO3
PubChem Compound IDCID 11289.
PubChem Substance IDSID 75427.
ChEBI3641;
SuperDrug ATC IDG03CA06
SuperDrug CAS ID000569573;
TargetEstrogen receptorBinder[2]
Ref 1Drug information of Chlorotrianisene, 2008 To Reference
Ref 2Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. FEBS Lett. 1990 Feb 12;261(1):59-62. To Reference



 

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