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TTD Drug ID: DAP001089

Drug Information
NameInsulin, porcine
SynonymsInsulin (Ox), 8A-L-threonine-10A-L-isoleucine- (9CI); Insulin,pig; Insulin (ox), 8(sup A)-L-threonine-10(sup A)-L-isoleucine-; Insulin (sperm whale); L-Alanine, L-phenylalanyl-L-valyl-L-asparaginyl-L-glutaminyl-L-histidyl-L-leucyl-L-cysteinylglycyl-L-seryl-L-histidyl-L-leucyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-leucyl-L-tyrosyl-L-leucyl-L-valyl-L-cysteinylglycyl-L-alpha-glutamyl-L-arginylglycyl-L-phenylalanyl-L-phenylalanyl-L-tyrosyl-L-threonyl-L-prolyl-L-lysyl-, cyclic (7-7'),(19-20')-bis(disulfide) with glycyl-L-isoleucyl-L-valyl-L-alpha-glutamyl-L-glytaminyl-L-cysteinyl-L-cysteinyl-L-threonyl-L-seryl-L-isolucyl-L-cysteinyl-L-seryl-L-leucyl-L-tyrosyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-asparaginyl-L-tyrosyl-L-cysteinyl-L-asparagine cyclic (6'-11')-disulfide; Porcine insulin; LS-84079; 184890-24-2; Insulin [pig]; Pig insulin; 12584-58-6; EINECS 235-703-3; Insulin [USAN:JAN]; Neutral insulin; Insulin porcine; Insulin (pig); Insulin (ox), 8A-l-threonine-10A-l-isoleucine-; Insulin (Canis familiaris); Swine insulin; Insulin, 8A-L-threonine-10A-L-isoleucine-; Insulin (Alopex lagopus); A neutral, buffered solution of pork insulin; Hog insulin; Insulin (swine); 97380-49-9; Insulin (ox); UNII-AVT680JB39; Insulin (porcine); Insulin, neutral; 8A-L-Threonine-10A-L-isoleucineinsulin (ox); 9004-14-2; Velosulin; Insulin (Physeter catodon); Insulin (dog)
IndicationDiabetes mellitus
[ICD9: 250   ICD10: E08-E13]
Approved    [1]
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
InChI1S/C256H381N65O76S6/c1-29-131(23)205(313-193(337)104-258)251(391)
317-204(130(21)22)247(387)288-159(75-82-200(347)348)217(357)282-1
56(71-78-189(262)333)221(361)308-183-116-401-402-117-184-242(382)
305-178(111-323)239(379)294-162(88-123(7)8)224(364)295-168(95-140
-53-61-146(327)62-54-140)227(367)283-154(69-76-187(260)331)218(35
8)290-161(87-122(5)6)222(362)285-158(74-81-199(345)346)220(360)30
2-174(101-190(263)334)234(374)298-170(97-142-57-65-148(329)66-58-
142)230(370)309-182(241(381)304-176(255(396)397)103-192(265)336)1
15-400-399-114-181(213(353)272-107-194(338)278-153(72-79-197(341)
342)216(356)281-151(51-42-84-270-256(266)267)211(351)271-108-195(
339)279-166(93-138-46-36-32-37-47-138)226(366)297-167(94-139-48-3
8-33-39-49-139)229(369)299-171(98-143-59-67-149(330)68-60-143)237
(377)320-208(136(28)326)253(393)321-85-43-52-186(321)245(385)286-
152(50-40-41-83-257)214(354)277-134(26)254(394)395)311-249(389)20
3(129(19)20)316-235(375)164(90-125(11)12)292-228(368)169(96-141-5
5-63-147(328)64-56-141)296-223(363)160(86-121(3)4)289-209(349)133
(25)276-215(355)157(73-80-198(343)344)287-246(386)202(128(17)18)3
15-236(376)165(91-126(13)14)293-232(372)173(100-145-106-269-120-2
75-145)301-238(378)177(110-322)280-196(340)109-273-212(352)180(11
3-398-403-118-185(310-243(183)383)244(384)319-207(135(27)325)252(
392)306-179(112-324)240(380)318-206(132(24)30-2)250(390)312-184)3
07-225(365)163(89-124(9)10)291-231(371)172(99-144-105-268-119-274
-144)300-219(359)155(70-77-188(261)332)284-233(373)175(102-191(26
4)335)303-248(388)201(127(15)16)314-210(350)150(259)92-137-44-34-
31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-208,3
22-330H,29-30,40-43,50-52,69-104,107-118,257-259H2,1-28H3,(H2,260
,331)(H2,261,332)(H2,262,333)(H2,263,334)(H2,264,335)(H2,265,336)
(H,268,274)(H,269,275)(H,271,351)(H,272,353)(H,273,352)(H,276,355
)(H,277,354)(H,278,338)(H,279,339)(H,280,340)(H,281,356)(H,282,35
7)(H,283,367)(H,284,373)(H,285,362)(H,286,385)(H,287,386)(H,288,3
87)(H,289,349)(H,290,358)(H,291,371)(H,292,368)(H,293,372)(H,294,
379)(H,295,364)(H,296,363)(H,297,366)(H,298,374)(H,299,369)(H,300
,359)(H,301,378)(H,302,360)(H,303,388)(H,304,381)(H,305,382)(H,30
6,392)(H,307,365)(H,308,361)(H,309,370)(H,310,383)(H,311,389)(H,3
12,390)(H,313,337)(H,314,350)(H,315,376)(H,316,375)(H,317,391)(H,
318,380)(H,319,384)(H,320,377)(H,341,342)(H,343,344)(H,345,346)(H
,347,348)(H,394,395)(H,396,397)(H4,266,267,270)/t131-,132-,133-,1
34-,135+,136+,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,1
60-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,1
73-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,1
86-,201-,202-,203-,204-,205-,206-,207-,208-/m0/s1
InChIKeyNOESYZHRGYRDHS-ZYCCASTOSA-N
Canonical SMILESCCC(C)C1C(=O)NC2CSSCC(C(=O)NC(CSSCC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)
NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)C
(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)CC(C)
C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)
NC(CC(=O)N)C(=O)O)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=
O)NC(CC5=CC=CC=C5)C(=O)NC(CC6=CC=CC=C6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(C
(C)O)C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(C)C(=O)O)C(C)C)CC(C)C)CC9=CC=C(C=
C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2=CN=CN2)CO)NC(=O)C(CC(C)C)NC(=O)C
(CC2=CN=CN2)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC2=
CC=CC=C2)N)C(=O)NC(C(=O)NC(C(=O)N1)CO)C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C(CCC
(=O)O)NC(=O)C(C(C)C)NC(=O)C(C(C)CC)NC(=O)CN    
Isomeric SMILESCC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)NCC
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC
(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@
@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CC(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)
CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)C(=
O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H]
(CC5=CC=CC=C5)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=
O)N[C@@H]([C@@H](C)O)C(=O)N8CCC[C@H]8C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C
(=O)O)C(C)C)CC(C)C)CC9=CC=C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2=
CN=CN2)CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CCC(=O)
N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=CC=C2)N)C(=O)
N[C@H](C(=O)N[C@H](C(=O)N1)CO)[C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@
H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CN
Therapeutic ClassHypoglycemic Agents
CAS NumberCAS 9004-14-2
FormulaC257H387N65O76S6
PubChem Compound IDCID 16131098.
PubChem Substance IDSID 727441.
SuperDrug ATC IDA10AB03; A10AC03; A10AD03; A10AE03
TargetInsulin receptorBinder[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor. J Biochem. 2002 Jun;131(6):855-9. To Reference



 

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