Therapeutic Targets Database
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TTD Drug ID: DAP001090

Drug Information
NameInsulin-detemir
IndicationDiabetes mellitus
[ICD9: 250   ICD10: E08-E13]
Approved    [1]
Structure

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Click to save drug structure in 2D MOL format
InChI1S/C267H402N64O76S6/c1-29-32-33-34-35-36-37-38-39-40-50-64-204(34
7)280-95-52-51-61-170(265(404)405)298-256(395)197-63-54-97-331(19
7)264(403)220(147(28)336)330-248(387)182(110-154-71-79-160(340)80
-72-154)309-240(379)178(106-150-59-48-43-49-60-150)307-237(376)17
7(105-149-57-46-42-47-58-149)289-207(350)120-282-223(362)162(62-5
3-96-281-267(276)277)291-227(366)163(84-91-209(352)353)288-206(34
9)119-283-225(364)192-126-409-410-127-193(252(391)314-187(266(406
)407)115-203(275)346)319-241(380)181(109-153-69-77-159(339)78-70-
153)308-245(384)185(113-201(273)344)312-231(370)168(86-93-211(356
)357)295-233(372)172(99-134(6)7)300-229(368)164(81-88-198(270)341
)293-238(377)179(107-151-65-73-157(337)74-66-151)305-235(374)173(
100-135(8)9)304-250(389)189(123-333)315-253(392)195-129-412-411-1
28-194(318-232(371)166(83-90-200(272)343)292-228(367)169(87-94-21
2(358)359)297-258(397)216(142(22)23)327-262(401)217(143(24)30-2)3
23-205(348)116-268)254(393)320-196(255(394)329-219(146(27)335)263
(402)316-190(124-334)251(390)328-218(144(25)31-3)261(400)322-195)
130-413-408-125-191(317-236(375)174(101-136(10)11)301-242(381)183
(111-155-117-278-131-285-155)310-230(369)165(82-89-199(271)342)29
4-244(383)186(114-202(274)345)313-259(398)213(139(16)17)324-222(3
61)161(269)104-148-55-44-41-45-56-148)224(363)284-121-208(351)290
-188(122-332)249(388)311-184(112-156-118-279-132-286-156)243(382)
303-176(103-138(14)15)247(386)325-214(140(18)19)257(396)296-167(8
5-92-210(354)355)226(365)287-145(26)221(360)299-171(98-133(4)5)23
4(373)306-180(108-152-67-75-158(338)76-68-152)239(378)302-175(102
-137(12)13)246(385)326-215(141(20)21)260(399)321-192/h41-49,55-60
,65-80,117-118,131-147,161-197,213-220,332-340H,29-40,50-54,61-64
,81-116,119-130,268-269H2,1-28H3,(H2,270,341)(H2,271,342)(H2,272,
343)(H2,273,344)(H2,274,345)(H2,275,346)(H,278,285)(H,279,286)(H,
280,347)(H,282,362)(H,283,364)(H,284,363)(H,287,365)(H,288,349)(H
,289,350)(H,290,351)(H,291,366)(H,292,367)(H,293,377)(H,294,383)(
H,295,372)(H,296,396)(H,297,397)(H,298,395)(H,299,360)(H,300,368)
(H,301,381)(H,302,378)(H,303,382)(H,304,389)(H,305,374)(H,306,373
)(H,307,376)(H,308,384)(H,309,379)(H,310,369)(H,311,388)(H,312,37
0)(H,313,398)(H,314,391)(H,315,392)(H,316,402)(H,317,375)(H,318,3
71)(H,319,380)(H,320,393)(H,321,399)(H,322,400)(H,323,348)(H,324,
361)(H,325,386)(H,326,385)(H,327,401)(H,328,390)(H,329,394)(H,330
,387)(H,352,353)(H,354,355)(H,356,357)(H,358,359)(H,404,405)(H,40
6,407)(H4,276,277,281)/t143-,144-,145-,146+,147+,161-,162-,163-,1
64-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,1
77-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187-,188-,189-,1
90-,191-,192-,193-,194-,195-,196-,197-,213-,214-,215-,216-,217-,2
18-,219-,220-/m0/s1
InChIKeyUGOZVNFCFYTPAZ-IOXYNQHNSA-N
Canonical SMILESCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)C1CCCN1C(=O)C(C(C)O)NC(=O)C(CC2=
CC=C(C=C2)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CC=CC=C4)NC(=O)CNC(=O)C
(CCCNC(=N)N)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C5CSSCC(NC(=O)C(NC(=O)C(NC(=O)
C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C6CSSCC(C(=O)NC(CSSCC(C
(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C
(=O)NC(C(=O)NC(C(=O)N5)C(C)C)CC(C)C)CC7=CC=C(C=C7)O)CC(C)C)C)CCC(=O)O)C
(C)C)CC(C)C)CC8=CNC=N8)CO)NC(=O)C(CC(C)C)NC(=O)C(CC9=CNC=N9)NC(=O)C(CCC
(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)N)C(=O)NC(C(=O)
NC(C(=O)NC(C(=O)N6)C(C)CC)CO)C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)O)NC
(=O)C(C(C)C)NC(=O)C(C(C)CC)NC(=O)CN)CO)CC(C)C)CC1=CC=C(C=C1)O)CCC(=O)N)
CC(C)C)CCC(=O)O)CC(=O)N)CC1=CC=C(C=C1)O)C(=O)NC(CC(=O)N)C(=O)O    
Isomeric SMILESCCCCCCCCCCCCCC(=O)NCCCC[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@@H]
(C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H]
(CC4=CC=CC=C4)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)
CNC(=O)[C@@H]5CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@
@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]
6CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N5)C(C)C)CC(C)C)CC7=CC=C(C=C7)O)CC(C)C)C)CCC(=O)
O)C(C)C)CC(C)C)CC8=CNC=N8)CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC9=CNC=N9)
NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H]
(CC1=CC=CC=C1)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N6)[C@@H](C)CC)
CO)[C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)
C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CN)CO)CC(C)C)CC1=CC=C(C=C1)O)CCC(=O)N)CC
(C)C)CCC(=O)O)CC(=O)N)CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(=O)N)C(=O)O
Therapeutic ClassHypoglycemic Agents
CAS NumberCAS 169148-63-4
FormulaC267H402N64O76S6
PubChem Compound IDCID 16137271.
SuperDrug ATC IDA10AE05
TargetInsulin receptorBinder[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2The role of insulin detemir in overweight type 2 diabetes management. Vasc Health Risk Manag. 2009;5(3):553-60. Epub 2009 Jun 29. To Reference



 

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