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TTD Drug ID: DAP001091

Drug Information
NameInsulin-glargine
SynonymsLantus; SoloStar [Insulin delivery pen]; A21-Gly-B31-Arg-B32-Arg-insulin; UNII-2ZM8CX04RZ; SoloStar; Insulin, glycyl(A21)-arginyl(B31,B32)-; Insulin glargine; Glargine; 160337-95-1
IndicationDiabetes mellitus
[ICD9: 250   ICD10: E08-E13]
Approved    [1]
Structure

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Click to save drug structure in 2D MOL format
InChI1S/C267H404N72O78S6/c1-29-137(23)212(330-199(355)109-269)260(412)
334-211(136(21)22)256(408)305-166(79-86-206(365)366)226(378)298-1
63(75-82-196(273)352)230(382)326-190-122-421-422-123-191-251(403)
322-185(117-341)249(401)312-170(94-129(7)8)234(386)313-176(101-14
6-57-65-152(346)66-58-146)237(389)299-161(73-80-194(271)350)227(3
79)308-169(93-128(5)6)232(384)301-165(78-85-205(363)364)229(381)3
20-182(107-197(274)353)244(396)316-178(103-148-61-69-154(348)70-6
2-148)240(392)325-188(222(374)290-115-207(367)368)120-418-420-121
-189(221(373)288-112-200(356)294-160(76-83-203(359)360)225(377)29
7-157(53-42-88-284-265(276)277)219(371)287-113-201(357)295-174(99
-144-48-36-32-37-49-144)236(388)315-175(100-145-50-38-33-39-51-14
5)239(391)317-179(104-149-63-71-155(349)72-64-149)247(399)338-216
(142(28)345)263(415)339-91-45-56-193(339)254(406)302-158(52-40-41
-87-268)231(383)336-214(140(26)343)261(413)303-159(54-43-89-285-2
66(278)279)224(376)306-167(264(416)417)55-44-90-286-267(280)281)3
28-258(410)210(135(19)20)333-245(397)172(96-131(11)12)310-238(390
)177(102-147-59-67-153(347)68-60-147)314-233(385)168(92-127(3)4)3
07-217(369)139(25)293-223(375)164(77-84-204(361)362)304-255(407)2
09(134(17)18)332-246(398)173(97-132(13)14)311-242(394)181(106-151
-111-283-126-292-151)319-248(400)184(116-340)296-202(358)114-289-
220(372)187(119-419-423-124-192(327-252(190)404)253(405)337-215(1
41(27)344)262(414)323-186(118-342)250(402)335-213(138(24)30-2)259
(411)329-191)324-235(387)171(95-130(9)10)309-241(393)180(105-150-
110-282-125-291-150)318-228(380)162(74-81-195(272)351)300-243(395
)183(108-198(275)354)321-257(409)208(133(15)16)331-218(370)156(27
0)98-143-46-34-31-35-47-143/h31-39,46-51,57-72,110-111,125-142,15
6-193,208-216,340-349H,29-30,40-45,52-56,73-109,112-124,268-270H2
,1-28H3,(H2,271,350)(H2,272,351)(H2,273,352)(H2,274,353)(H2,275,3
54)(H,282,291)(H,283,292)(H,287,371)(H,288,373)(H,289,372)(H,290,
374)(H,293,375)(H,294,356)(H,295,357)(H,296,358)(H,297,377)(H,298
,378)(H,299,389)(H,300,395)(H,301,384)(H,302,406)(H,303,413)(H,30
4,407)(H,305,408)(H,306,376)(H,307,369)(H,308,379)(H,309,393)(H,3
10,390)(H,311,394)(H,312,401)(H,313,386)(H,314,385)(H,315,388)(H,
316,396)(H,317,391)(H,318,380)(H,319,400)(H,320,381)(H,321,409)(H
,322,403)(H,323,414)(H,324,387)(H,325,392)(H,326,382)(H,327,404)(
H,328,410)(H,329,411)(H,330,355)(H,331,370)(H,332,398)(H,333,397)
(H,334,412)(H,335,402)(H,336,383)(H,337,405)(H,338,399)(H,359,360
)(H,361,362)(H,363,364)(H,365,366)(H,367,368)(H,416,417)(H4,276,2
77,284)(H4,278,279,285)(H4,280,281,286)/t137-,138-,139-,140+,141+
,142+,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-
,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-
,181-,182-,183-,184-,185-,186-,187-,188-,189-,190-,191-,192-,193-
,208-,209-,210-,211-,212-,213-,214-,215-,216-/m0/s1
InChIKeyCOCFEDIXXNGUNL-RFKWWTKHSA-N
Canonical SMILESCCC(C)C1C(=O)NC2CSSCC(C(=O)NC(CSSCC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)
NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)C
(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)CC(C)
C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)
NCC(=O)O)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC5=
CC=CC=C5)C(=O)NC(CC6=CC=CC=C6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(C(C)O)C(=
O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=
N)N)C(=O)O)C(C)C)CC(C)C)CC9=CC=C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)
CC2=CN=CN2)CO)NC(=O)C(CC(C)C)NC(=O)C(CC2=CN=CN2)NC(=O)C(CCC(=O)N)NC(=O)C
(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC2=CC=CC=C2)N)C(=O)NC(C(=O)NC(C(=O)N1)
CO)C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(C(C)CC)
NC(=O)CN    
Isomeric SMILESCC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)NCC
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC
(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@
@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CC(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)
CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)NCC(=O)O)C(=O)NCC(=O)N[C@@
H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC5=CC=CC=C5)C(=
O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)N[C@@H]([C@@H]
(C)O)C(=O)N8CCC[C@H]8C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N
[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)CC(C)C)CC9=CC=C
(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2=CN=CN2)CO)NC(=O)[C@H](CC(C)C)
NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)
[C@H](C(C)C)NC(=O)[C@H](CC2=CC=CC=C2)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)
CO)[C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)
C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CN
Therapeutic ClassHypoglycemic Agents
CAS NumberCAS 160337-95-1
FormulaC267H408N72O77S6
PubChem Compound IDCID 44146714.
PubChem Substance IDSID 3818115.
SuperDrug ATC IDA10AE04
A10AE04
TargetInsulin receptorBinder[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Safe and Simple Emergency Department Discharge Therapy for Type 2 Diabetes Patients with Severe Hyperglycemia. Endocr Pract. 2009 Jul 20:1-26. [Epub ahead of print] To Reference



 

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