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TTD Drug ID: DAP001129

Drug Information
NameSolifenacin
SynonymsQuinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylatemonosuccinate; Vesikur; CHEMBL1734; 1-azabicyclo[2.2.2]octan-3-yl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; 242478-37-1; 242478-38-2; [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; butanedioic acid; CID216457; UNII-A8910SQJ1U; YM-905; AC1L9FFR; MolPort-003-850-268; LS-183550; Solifenacin succinate; DB01591; NCGC00168778-01; Butanedioic acid, cmpd. with (1S)-(3R)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1); CID154059; AR-1L5425; YM 905; 1-azabicyclo[2.2.2]oct-8-yl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; AC1L50Q6; Solifenacin (INN); CID443938; AC1L4BM3; Butanedioic acid, compd with (1S)-(3R)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1); 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-,1-azabicyclo(2.2.2)oct-3-yl ester, (R-(R*,S*))-; Solifenacin [INN:BAN]; Solifenacin; 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, (3R)-1-azabicyclo(2.2.2)oct-3-yl ester, (1S)-, butanedioate (1:1); YM-67905; YM-53705; Vesicare; D08522; AC1Q5VRD; [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; UNII-KKA5DLD701; Solifenacin succinate [USAN]; CHEMBL1200803
Trade NameVesicare
CompanyGlaxoSmithKline
IndicationOveractive bladder
[ICD9: 596.51   ICD10: N32.81]
Approved    [1]
Structure

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InChI1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-1
5-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,
18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21-,22-;/m0./s1
InChIKeyRXZMMZZRUPYENV-VROPFNGYSA-N
Canonical SMILESC1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5.C(CC(=O)O)C(=O)O    
Isomeric SMILESC1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5.C(CC(=O)O)C(=
O)O
Therapeutic ClassAntispasmodics
CAS NumberCAS 242478-37-1
FormulaC27H32N2O6
PubChem Compound IDCID 216457.
PubChem Substance IDSID 789631.
SuperDrug ATC IDG04BD08
SuperDrug CAS ID000059961;
TargetMuscarinic acetylcholine receptor M3Antagonist[2]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021518 To Reference
Ref 2Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice. Eur J Pharmacol. 2009 Aug 1;615(1-3):201-6. Epub 2009 May 13. To Reference



 

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