Therapeutic Targets Database
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TTD Drug ID: DAP001141

Drug Information
NameEthionamide
Synonyms1314-Th; NCGC00091074-02; Tuberoid; Prestwick1_000526; Isonicotinamide, 2-ethylthio-; SPBio_002432; HMS1920M22; alpha-Ethylisothionicotinamide; 2-Ethylisothionicotinamide; Prestwick3_000526; 2-Ethylthioisonicotinamide; WLN: T6NJ B2 DYZUS; SAM002554899; Prestwick2_000526; DivK1c_000145; Spectrum3_000428; 1314 TN; Nisotin; NCGC00016497-01; Tiomid; D00591; SMR001370750; BPBio1_000563; E0695; SPBio_001087; Aethionamidum; CPD001370750; NCGC00091074-03; Fatoliamid; Tuberoson; 2-ethylisonicotinic acid thiomide; 2-ethyl-4-aminothiocarbonylpyridine; Trecator SC; Aetiva; Amidazine; Etionamida; NCI-C01694; 536-33-4; Etionamide [DCIT]; Trecator-SC; .alpha.-Ethyl-thioisonicotinamide; 2-Ethylisonicotinothioamide; Etiocidan; 3-Ethylisothionicotinamide; Trekator; 2-Ethylisonicotinic thioamide; C8H10N2S; Isothin; 2-e thylisothionicotinamide; Rigenicid; Iridozin; 2-ETHYL-4-PYRIDINECARBOTHIOAMIDE; Ethina (VAN); .alpha.-Ethylisonicotinoylthioamide; Isotiamida; C07665; HMS2091F03; Ethyonomide; HSDB 7473; Tubenamide; Thianide; .alpha.-Ethylthioisonicotinamide; 1314 TH; S1777_Selleck; Etionamid; alpha-Ethylisonicotinoylthioamide; MolPort-000-159-777; Ethylisothiamide; CID2761171; MLS002454402; CAS-536-33-4; SPECTRUM1500292; Trescatyl; HMS1569J13; Thiomid; Etionizine; Atina; Etionamida [INN-Spanish]; 2-Ethyl-thioisonicotinamide; Etionizin; NCGC00091074-01; alpha-Ethylthioisonicotinamide; AC1MC4CB; Nicotion; BSPBio_002016; Ethionamidum; .alpha.-Ethylisothionicotinamide; Ethionamid prothionamid; Prestwick_842; Tubermin; KBio3_001236; NSC255115; Trecator; 2-Ethylisonicotinic acid thioamide; AB00051990; .alpha.-Ethylisonicotinic acid thioamide; Thioamide; Ethionamide (JP15/USP/INN); Etionid; MLS001074114; UNII-OAY8ORS3CQ; E6005_SIGMA; Ethimide; 2-Ethyl-4-thiocarbamoylpyridine; Iridocin Bayer; SMR000058716; Bayer5312; Tianid; Spectrum5_000979; SBB055548; Isonicotinimidic acid, 2-ethylthio-; alpha-ethylt hioisonicotinamide; DB00609; D005000; NSC 255115; CHEMBL1441; alpha-Ethylisonicotinic acid thioamide; TH 1314; Spectrum_001082; Bayer 5312; Amidazin; KBioSS_001562; CHEBI:4885; NINDS_000145; 2-ethylthioisonicotinamide, Trecator SC, Amidazine, Ethionamide; Wyeth Brand of Ethionamide; 1314TH; IDI1_000145; Trecator-SC (TN); Iridocin; KBioGR_001213; 2-Ethylisonicotinoylthioamide; Ethionamidum [INN-Latin]; Etionamide; BRD-K33710385-001-05-4; Sertinon; ethionamide; HMS500H07; Thianid; Aetina; NCGC00091074-04; Prestwick0_000526; AEOCXXJPGCBFJA-UHFFFAOYSA-; MLS000069764; Ethionamide [USAN:INN:BAN:JAN]; BSPBio_000511; Ethatyl; KBio2_004130; AC-13715; BRN 0116474; Thioniden; KBio2_006698; 4-Pyridinecarbothioamide, 2-ethyl-; KBio1_000145; ZINC03872520; Itiocide; InChI=1/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11); Trescazide; Teberus; LS-199; 2-ethylpyridine-4-carbothioamide; Etioniamid; Nizotin; Spectrum2_000994; Ethioniamide; Spectrum4_000547; 2-Ethyl-4-thioamidylpyridine; Ethina; KBio2_001562; F.I. 58-30; :ethionamide; Etimid; EINECS 208-628-9; Ethinamide; Etionizina; 5-22-02-00360 (Beilstein Handbook Reference); CCRIS 287; Tio-Mid
IndicationTuberculosis
[ICD9: 010-018   ICD10: A15-A19]
Approved    [1]
Structure

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InChI1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
InChIKeyAEOCXXJPGCBFJA-UHFFFAOYSA-N
Canonical SMILESCCC1=NC=CC(=C1)C(=S)N    
Therapeutic ClassAntituberculosis Agents
CAS NumberCAS 536-33-4
FormulaC8H10N2S
PubChem Compound IDCID 2761171.
PubChem Substance IDSID 9867.
ChEBI4885;
SuperDrug ATC IDJ04AD03
SuperDrug CAS ID000536334;
TargetMycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (inhA)Inhibitor[2][3]
Ref 1Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8. To Reference
Ref 2Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16. To Reference
Ref 3Calcium-activated conductance in skate electroreceptors: current clamp experiments. J Gen Physiol. 1977 Feb;69(2):121-43. To Reference



 

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