Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DAP001142

Drug Information
NameProthionamide
SynonymsMLS001201789; EINECS 238-093-7; MolPort-000-159-776; Protionamide (INN); HMS2090J11; RP 9778; 2-Propyl-thioisonicotinamide; KBio3_002911; NCGC00095164-02; I06-0623; STK366469; AC1LDFXW; AC-4518; UNII-76YOO33643; LS-84822; NCGC00095164-03; Trevintix (TN); MLS000042521; HMS1922D06; 1321 TH; Protionamidum; Spectrum3_001964; SPECTRUM1505316; Isonicotinamide, 2-propylthio-; ZINC03874803; Protionamide [INN:DCF]; SPBio_000057; Spectrum2_000019; 2-Propylthioisonicotinamide; Protionizina; Prothionamide (JP15); TH-1321; 5-22-02-00376 (Beilstein Handbook Reference); 14222-60-7; 2-Propylisonicotinylthioamide; BSPBio_003564; Prothionamidum; BRN 0118164; Tebeform; 9778 R.P.; 9778 R.P; SMR000047660; Protionamidum [INN-Latin]; Tuberex; Peteha; Protionamida; 4-Pyridinecarbothioamide, 2-propyl-; TH 1321; C9H12N2S; BB_SC-2027; Ektebin; 2-propylpyridine-4-carbothioamide; CID666418; Protionamid; 2-Propyl-4-thiocarbamoylpyridine; 2-Propyl-4-pyridinecarbothioamide; NCGC00095164-01; Protionamida [INN-Spanish]; D01195; 4-Pyridinecarbothioamide, 2-propyl- (9CI); prothionamide; Trevintix; Protionamide
IndicationTuberculosis
[ICD9: 010-018   ICD10: A15-A19]
Approved    [1]
Structure

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InChI1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,
12)
InChIKeyVRDIULHPQTYCLN-UHFFFAOYSA-N
Canonical SMILESCCCC1=NC=CC(=C1)C(=S)N    
Therapeutic ClassAntituberculosis Agents
CAS NumberCAS 14222-60-7
FormulaC9H12N2S
PubChem Compound IDCID 666418.
PubChem Substance IDSID 169286.
SuperDrug ATC IDJ04AD01
SuperDrug CAS ID014222607;
TargetMycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (inhA)Inhibitor[1][2]
Ref 1Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16. To Reference
Ref 2Ability of the Ca2+ ionophores A23187 and ionomycin to mimic some of the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production, ornithine decarboxylase activity, and DNA synthesis in mouse epidermis in vivo. Cancer Res. 1990 Sep 15;50(18):5806-12. To Reference



 

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