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TTD Drug ID: DAP001220

Drug Information
NameRemikiren
Synonyms(S)-alpha-((S)-alpha-((t-butylsulfonyl)methyl)hydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl)imidazole-4-propionamide; CHEMBL31601; LS-172931; (2R)-2-benzyl-3-tert-butylsulfonyl-N-[(2S)-1-[[(2R,3S,4R)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]propanamide; 135669-48-6; CCRIS 6519; Remikiren; 1H-Imidazole-4-propanamide, N-(1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl)-alpha-((2-(((1,1-dimethylethyl)sulfonyl)methyl)-1-oxo-3-phenylpropyl)amino)-, (1S-(1R*(R*(R*)),2S*,3R*))-; AC1NUWCS; AC1O44IV; LS-78865; C33H50N4O6S; CHEBI:142751; CID5462340; Remikiren [INN]; Remikiren (INN); CID5230731; D09038; UNII-LC7FBL96A4; 126222-34-2; (2S)-2-benzyl-3-tert-butylsulfonyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]propanamide; DB00212; Ro-42-5892; AC1NQY7T; CID6324659; REM; C07465; (alphaS)-alpha-((alphaS)-alpha-((tert-Butylsulfonyl)methyl)hydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl)imidazole-4-propionamide; 2-benzyl-3-tert-butylsulfonyl-N-[1-[(1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl)amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]propanamide; Ro 42-5892
CompanyHoffmann-La Roche pharmaceutical company
IndicationHypertension
[ICD9: 401   ICD10: I10, I11, I12, I13, I15]
Approved    [1]
Structure

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InChI1S/C33H50N4O6S/c1-33(2,3)44(42,43)20-25(16-22-10-6-4-7-11-22)31(4
0)37-28(18-26-19-34-21-35-26)32(41)36-27(17-23-12-8-5-9-13-23)30(
39)29(38)24-14-15-24/h4,6-7,10-11,19,21,23-25,27-30,38-39H,5,8-9,
12-18,20H2,1-3H3,(H,34,35)(H,36,41)(H,37,40)/t25-,27+,28+,29+,30-
/m1/s1
InChIKeyUXIGZRQVLGFTOU-VQXQMPIVSA-N
Canonical SMILESCC(C)(C)S(=O)(=O)CC(CC1=CC=CC=C1)C(=O)NC(CC2=CN=CN2)C(=O)NC(CC3CCCCC3)C
(C(C4CC4)O)O    
Isomeric SMILESCC(C)(C)S(=O)(=O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@
H](CC3CCCCC3)[C@H]([C@H](C4CC4)O)O
Therapeutic ClassAntihypertensive Agents
CAS NumberCAS 126222-34-2
FormulaC33H50N4O6S
PubChem Compound IDCID 6324659.
PubChem Substance IDSID 7980504.
SuperDrug ATC IDC09XA01
SuperDrug CAS ID012622234;
TargetReninInhibitor[1]
Ref 1Functional expression of the renin-angiotensin system in human podocytes. Am J Physiol Renal Physiol. 2006 Mar;290(3):F710-9. Epub 2005 Sep 27. To Reference



 

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