Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DAP001244

Drug Information
IndicationColon Cancer
[ICD9: 153, 154   ICD10: C18-C21]
Approved    [1]

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Canonical SMILESC1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O    
Isomeric SMILESC1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@H](CCC(=O)O)C(=O)O
Therapeutic ClassVitamins
CAS NumberCAS 1492-18-8
PubChem Compound IDCID 54575.
SuperDrug ATC IDV03AF03
SuperDrug CAS ID001492188;
TargetThymidylate synthaseInhibitor[2][3]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance. Mol Cancer Ther. 2009 Apr 21. [Epub ahead of print] To Reference
Ref 3Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward? Cancer Biol Ther. 2008 Jul;7(7):986-94. Epub 2008 Apr 21. To Reference


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