Therapeutic Targets Database
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TTD Drug ID: DAP001245

Drug Information
NameFloxuridine/5-fluorouracil
Trade NameFUDR
CompanyRoche Pharmaceuticals
IndicationColorectal cancer
[ICD9: 153, 154   ICD10: C18-C21]
Approved    [1]
Structure

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InChI1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5
-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChIKeyODKNJVUHOIMIIZ-RRKCRQDMSA-N
Canonical SMILESC1C(C(OC1N2C=C(C(=O)NC2=O)F)CO)O    
Isomeric SMILESC1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 50-91-9
FormulaC9H11FN2O5
PubChem Compound IDCID 5790.
SuperDrug ATC IDL01BC02
SuperDrug CAS ID000051218;
TargetThymidylate synthaseInhibitor[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells. Br J Pharmacol. 1999 Aug;127(8):1777-86. To Reference



 

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