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TTD Drug ID: DAP001328

Drug Information
NameDaptomycin
Synonyms103060-53-3; D01080; MolPort-003-846-138; C12013; DAPTOMYCIN; Dapcin; N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine; MK-3009; N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone; Daptomicina [Spanish]; CHEMBL508162; Daptomycine [French]; N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox; N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone; UNII-NWQ5N31VKK; Daptomycine; AKOS005146218; Daptomycinum; N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone; Daptomycin [USAN:INN:BAN]; Cubicin (TN); CHEBI:600103; Deptomycin; Daptomycin (JAN/USAN/INN); nchembio.184-comp5; N-decanoyl-L-tryptophyl-D-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine; Daptomycinum [Latin]; Cidecin; C72H101N17O26; LY146032; LS-171846; Cubicin; Daptomicina; LY-146032
Trade NameCubicin
CompanyCubist Pharmaceuticals
IndicationBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
Approved    [1]
Structure

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InChI1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42
-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59
(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-
41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(9
5)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(1
00)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,1
7-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H
3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82
,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(
H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)
InChIKeyDOAKLVKFURWEDJ-UHFFFAOYSA-N
Canonical SMILESCCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=
O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC
(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C    
Therapeutic ClassAntibacterial Agents
CAS NumberCAS 103060-53-3
FormulaC72H101N17O26
PubChem Compound IDCID 16129688.
PubChem Substance IDSID 196199.
SuperDrug ATC IDJ01XX09
J01XX09
TargetBacterial outer membraneBinder[2]
Ref 1How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30. To Reference
Ref 2Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol. 2004 Jul;11(7):949-57. To Reference



 

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