Therapeutic Targets Database
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TTD Drug ID: DAP001337

Drug Information
NameTroglitazone
Synonyms2,4-thiazolidinedione, 5-[[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-; DB00197; BRD-A13084692-001-02-5; 2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-; 2,4-Thiazolidinedione, 5-[[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]- (9CI); C057693; AC1L1KOT; CS 045; Resulin; Rezulin (TN); troglitazone; HMS2093D04; Noscal; AKOS000281116; Warner-Lambert brand of troglitazone; I14-1977; 5-(4-((6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione); CS-045; Troglitazone (JAN/USAN/INN); UPCMLD-DP017; BRN 4338399; HMS2089D22; CPD-11439; SMP2_000224; Spectrum5_001973; NCGC00161599-01; (+/-)-5-[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione; 97322-87-7; D00395; CID5591; CI-991; CHEMBL408; NCGC00161599-03; Ambap97322-87-7; C24H27NO5S; CHEBI:9753; GR 92132X; NCGC00164445-01; Parke Davis brand of troglitazone; troglitazonum; T2573_SIGMA; CI 991; GR-92132X; 5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione; UNII-I66ZZ0ZN0E; UPCMLD-DP017:001; (+-)-all-rac-5-(p-((6-Hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione; Troglitazone [USAN:BAN:INN]; Prelay; troglitazona; HSCI1_000037; 5-[(4-{[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methyl]oxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione; CCRIS 8969; Romozin; UPCMLD-DP017:002; NCGC00161599-02; LS-151313; Rezulin; 5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione; MolPort-003-666-725; MolPort-000-883-772; 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione; Romglizone; 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Trade NameRezulin; Resulin; Romozin
CompanyDaiichi Sankyo Pharma Development
IndicationDiabetes mellitus
[ICD9: 250   ICD10: E08-E13]
Approved    [1]
Structure

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InChI1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-2
9-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,
1-4H3,(H,25,27,28)
InChIKeyGXPHKUHSUJUWKP-UHFFFAOYSA-N
Canonical SMILESCC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O    
Therapeutic ClassAnti-Inflammatory Agents
CAS NumberCAS 97322-87-7
FormulaC24H27NO5S
PubChem Compound IDCID 5591.
PubChem Substance IDSID 194350.
ChEBI9753;
SuperDrug ATC IDA10BG01
SuperDrug CAS ID097322877;
TargetPeroxisome proliferator activated receptor gammaAgonist[2][3][4]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists. Int J Cancer. 2003 May 1;104(5):597-602. To Reference
Ref 3Nat Rev Drug Discov. 2003 Jan;2(1):38-51.Knockouts model the 100 best-selling drugs--will they model the next 100? To Reference
Ref 4Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat Med. 2002 Nov;8(11):1281-7. Epub 2002 Oct 15. To Reference



 

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