Therapeutic Targets Database
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TTD Drug ID: DAP001348

Drug Information
NameDhaq diacetate
Synonyms1,4-Dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione diacetate; 65271-80-9 (Parent); 5,8-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxy-9,10-anthracenedione diacetate; Dhaq diacetate; 70711-41-0; 2-[[5,8-dihydroxy-4-[2-(2-hydroxyethylazaniumyl)ethylamino]-9,10-dioxoanthracen-1-yl]amino]ethyl-(2-hydroxyethyl)azanium diacetate; Anthraquinone, 5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxy-, 1,4-diacetate (salt); AC1L1AJM; 5,8-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone 1,4-diaceate; LS-20639; CID51151; NSC 299195; Mitoxantrone diacetate
IndicationCancer
[ICD9: 140-229   ICD10: C00-C96]
Approved    [1]
Structure

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InChI1S/C22H28N4O6.2C2H4O2/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-1
2-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;2*1-2(3)4/h
1-4,23-30H,5-12H2;2*1H3,(H,3,4)
InChIKeyZWCKUVMZBKQQRG-UHFFFAOYSA-N
Canonical SMILESCC(=O)[O-].CC(=O)[O-].C1=CC(=C2C(=C1NCC[NH2+]CCO)C(=O)C3=C(C=CC(=C3C2=O)
O)O)NCC[NH2+]CCO    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 70711-41-0
FormulaC26H36N4O10
PubChem Compound IDCID 51151.
PubChem Substance IDSID 189409.
TargetDNA topoisomerase IIInhibitor[1][2]
Ref 1The hypoxia-activated ProDrug AQ4N penetrates deeply in tumor tissues and complements the limited distribution of mitoxantrone. Cancer Res. 2009 Feb 1;69(3):940-7. Epub 2009 Jan 27. To Reference
Ref 2Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells. J Biol Chem. 2000 Aug 18;275(33):25231-8. To Reference



 

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