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TTD Drug ID: DAP001353

Drug Information
NameBuprenex
SynonymsDB00921; CID40400; 52485-79-7; AC1L9B1P; 6,14-ethenomorphinan-3-ol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-, (5alpha,7alpha)-; ETI-311; (-)-buprenorphine; BEMA long acting analgesic; CID11969480; AC1LD8IH; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, hydrochloride, (5-alpha,7-alpha(S))-; 52485-79-7 (Parent); Buprenorfina; RX-6029-M; Temgesic; CL 112302; NIH 8805; AC1L23NL; MolPort-003-983-827; C08007; Buprenophine; TSN-09; Buprenorphine hydrochloride [USAN:JAN]; Subutex; EINECS 257-950-6; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5-alpha,7-alpha-(S))-; 21-Cyclopropyl-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine hydrochloride; 2-(N-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-7alpha-yl)-3,3-dimethyl-2-butanol; CL 112,302; 17-cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol; IX-1005; LS-67682; [5alpha,7alpha(S)]-17-(Cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol; Finibron; DEA No. 9064; (5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol; RX 6029M; [5alpha,7alpha(S)]-; 53187-13-6; Buprex; C29H41NO4.HCl; Buprenorphinum; AC1MHV55; MolPort-004-285-844; 2-(N-cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol; Buprenorphine [INN:BAN]; Transtec; LS-67683; Buprenex; MR 56; UNII-56W8MW3EN1; Buprenorphine hydrochloride (JAN/USP); 21-cyclopropyl-7alpha-(2-hydroxy-3,3-dimethyl-2-butyl)-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-,; UM-952; D00836; 21-cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, hydrochloride, (5alpha,7alpha(S))-; IX-1003; EINECS 258-396-8; BEMA-buprenorphine; MolPort-006-393-069; CHEMBL1200401; RX 6029-M; (5alpha,7alpha(S))-alpha-tert-Butyl-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol hydrochloride; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (alphaS,5alpha,7alpha)- (9CI); IX-1004; CID644073; CID441364; 17-Cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6-methoxy-6,14-endo-ethanomorphinan-3-ol; Butrans; Norspan; V-1005; 21-(Cyclopropyl-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 6029-M; 64425-21-4; CL-112302; CHEBI:3216; C29H41NO4; V-1004; NIH-8805; Buprel; 55327-62-3; UNII-40D3SCR4GZ; Buprenorphine Depot; CID3033050; Buprenorphinum [INN-Latin]; 53152-21-9; BUPRENORPHINE HYDROCHLORIDE; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-; BEMA LA; Buprenorfina [INN-Spanish]; 53152-21-9 (hydrochloride); UM 952; Buprenorphine Hcl; Buprenex (TN); Probuphine; V-1003; buprenorphine
Trade NameTemgesic; Buprenex
CompanyReckitt Benckiser Phamaceuticals
IndicationPain
[ICD9: 338,780   ICD10: R52, G89]
Approved    [1]
Structure

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InChI1S/C29H41NO4.ClH/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-2
8(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)2
8;/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3;1H/t20-,21-,24-,26?,
27-,28+,29-;/m1./s1
InChIKeyUAIXRPCCYXNJMQ-CYVYHKOSSA-N
Canonical SMILESCC(C)(C)C(C)(C1CC23CCC1(C4C25CCN(C3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O.Cl    
Isomeric SMILESCC(C)(C)C(C)([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C
(C=C6)O)O4)CC7CC7)OC)O.Cl
Therapeutic ClassAnalgesics
CAS NumberCAS 52485-79-7
FormulaC29H41NO4
PubChem Compound IDCID 5281091.
PubChem Substance IDSID 49968731.
SuperDrug ATC IDN02AE01; N07BC01
SuperDrug CAS ID052485797;
TargetMu-type opioid receptorAgonist[2]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018401 To Reference
Ref 2Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization. J Neurosci. 2009 Jun 3;29(22):7341-8. To Reference



 

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