Therapeutic Targets Database
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TTD Drug ID: DAP001391

Drug Information
NameHydroxyflutamide
Synonymshydroxy-flutamide; Hydroxyniphtholide; Hydroxyflutamide; ZINC04655055; LS-119288; 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide; Propanamide, 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-; CHEMBL491; HFT; AC1Q1LI1; NCGC00091014-01; MLS001061267; AR-1E2288; MolPort-001-771-895; SMR001227196; 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; CID91649; OH-flutamide; 52806-53-8; CHEBI:106787; BIDD:ER0519; CHEBI:43064; Sch-16423; AC1L3MI1; alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide; FT-0080575; S2174_Selleck; C14204; PC1193; Sch 16423; EN001669; C014290; alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide
IndicationProstate cancer
[ICD9: 185   ICD10: C61]
Approved    [1]
Structure

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InChI1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,1
3)14/h3-5,18H,1-2H3,(H,15,17)
InChIKeyYPQLFJODEKMJEF-UHFFFAOYSA-N
Canonical SMILESCC(C)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 52806-53-8
FormulaC11H11F3N2O4
PubChem Compound IDCID 91649.
PubChem Substance IDSID 668442.
TargetAndrogen receptorAntagonist[1][2][3]
Ref 1Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol. 2007 Apr;4(4):236-44. To Reference
Ref 2Ectopic expression of the amino-terminal peptide of androgen receptor leads to androgen receptor dysfunction and inhibition of androgen receptor-mediated prostate cancer growth. Mol Cell Endocrinol. 2004 Feb 12;214(1-2):175-87. To Reference
Ref 3Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor. Biochem Pharmacol. 1998 May 1;55(9):1427-33. To Reference



 

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