Therapeutic Targets Database
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TTD Drug ID: DAP001427

Drug Information
NameSarpogrelate
SynonymsSarpogrelate [INN]; 4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}propan-2-yl]oxy}-4-oxobutanoic acid; Sarpogrelate (INN); D08508; 125926-17-2; UNII-19P708E787; butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester; CID5160; AR-1I1045; AC1L1JQL; AC1Q5VS0; L000858; CHEMBL52939; STK631325; CHEBI:180532; 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid; LS-187118; NCGC00167489-01; 135309-80-7
IndicationDiabetes mellitus
[ICD9: 250   ICD10: E08-E13]
Approved    [1]
Structure

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InChI1S/C24H31NO6/c1-25(2)16-21(31-24(28)14-13-23(26)27)17-30-22-10-5-
4-8-19(22)12-11-18-7-6-9-20(15-18)29-3/h4-10,15,21H,11-14,16-17H2
,1-3H3,(H,26,27)
InChIKeyFFYNAVGJSYHHFO-UHFFFAOYSA-N
Canonical SMILESCN(C)CC(COC1=CC=CC=C1CCC2=CC(=CC=C2)OC)OC(=O)CCC(=O)O    
Therapeutic ClassHypoglycemic Agents
CAS NumberCAS 125926-17-2
FormulaC24H31NO6
PubChem Compound IDCID 5160.
PubChem Substance IDSID 3862730.
Target5-hydroxytryptamine 2A receptorAntagonist[2][3][3][4]
Ref 1A 50-year history of new drugs in Japan-the development and trends of hemostatics and antithrombotic drugs. Yakushigaku Zasshi. 2003;38(1):93-105. To Reference
Ref 2Beneficial effects of sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, supplemented with pioglitazone on diabetic model mice. Endocr Res. 2009;34(1-2):18-30. To Reference
Ref 3Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats. Eur J Pharmacol. 2009 Jul 1;614(1-3):122-7. Epub 2009 Mar 24. To Reference
Ref 4Therapeutic effect of sarpogrelate, a new 5-hydroxytryptamine receptor 2A antagonist, on diabetic nephropathy and neuropathy. Nephron. 1997;76(2):227-9. To Reference



 

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