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TTD Drug ID: DAP001432

Drug Information
NameTetrodotoxin
SynonymsT5651_SIGMA; HSDB 3543; TETRODOTOXIN; Spheroidine; 4-27-00-08206 (Beilstein Handbook Reference); BRN 0049176; BJT 1; 9014-39-5; Tetrodotoxine; CID20382; AC1L2G5D; LS-62012; CHEBI:9506; 2229-61-0; Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10adimethano-10aH-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol; 12626-86-7; (1r,5r,6r,9r,11s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.17,11.01,6]tetradec-3-ene-5,9,12,13,14-pentol(non-preferred name); AC1Q6Z79; (1R,5R,6R,7R,9S,11R,12R,13S,14S)-14-(hydroxymethyl)-3-imino-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1(7,11).0(1,6)]tetradecane-5,9,12,13,14-pentol; CID5460547; Maculotoxin; 4368-28-9; C11H17N3O8.H; CHEMBL507974; 5,9:7,10a-Dimethano-10aH-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol, octahydro-12-(hydroxymethyl)-2-imino-, (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-; Tetradotoxin; CCRIS 9328; MolPort-003-959-757; 11026-09-8; EINECS 224-458-8; Babylonia japonica toxin 1; CID11174599; 11005-69-9; Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol; T8024_SIGMA; Fugu Toxin; 17289-88-2; Fugu poison; 5,9:7,10a-Dimethano-10aH-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol, octahydro-12-(hydroxymethyl)-2-imino-; Tetrodoxin; (4R-(4alpha,4aalpha,5alpha,7alpha,9alpha,10alpha,10abeta,11S*,12S*))-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-(1,3)dioxocino(6,5-d) pyrimidine-4,7,10,11,12-pentol; 5,9:7,10a-Dimethano-10ah-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol, octahydro-12-(hydroxymethyl)-2-imino-, (4R-(4alpha,4aalpha,5alpha,7alpha,9alpha,10alpha,10abeta,11S*,12S*))-; TTX; Tetrodontoxin; Tarichatoxin
IndicationBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
Approved    [1]
Structure

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InChI1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)1
1(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3?,4+,5+,6-,7+,9
+,10-,11-/m1/s1
InChIKeyCFMYXEVWODSLAX-XMVQEDPJSA-N
Canonical SMILESC(C1(C2C3C(N=C(NC34C(C1OC(C4O)(O2)O)O)N)O)O)O    
Isomeric SMILESC([C@@]1([C@@H]2[C@@H]3[C@H](N=C(N[C@]34[C@@H]([C@@](O2)(O[C@H]1C4O)O)O)
N)O)O)O
Therapeutic ClassAntibacterial Agents
CAS NumberCAS 4368-28-9
PubChem Compound IDCID 20382.
PubChem Substance IDSID 163204.
ChEBI9506;
TargetSodium channel protein type 5 subunit alphaBlocker[1]
Ref 1Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81. To Reference



 

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