Therapeutic Targets Database
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TTD Drug ID: DAP001451

Drug Information
NameTyverb/Tykerb
CompanyGSK
IndicationGastric cancer
[ICD9: 151   ICD10: C16]
Phase III    [1]
Head & neck squamous cell carcinoma
[ICD9: 199   ICD10: C44]
Phase II    [1]
Refractory breast cancer
[ICD9: 174, 175   ICD10: C50]
Approved    [1]
Structure

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InChI1S/C23H24N4O6/c1-30-20-10-17(5-6-19(20)21-12-24-14-32-21)27-22(28
)26-16-4-2-3-15(9-16)11-25-23(29)33-18-7-8-31-13-18/h2-6,9-10,12,
14,18H,7-8,11,13H2,1H3,(H,25,29)(H2,26,27,28)/t18-/m0/s1
InChIKeyJBPUGFODGPKTDW-SFHVURJKSA-N
Canonical SMILESCOC1=C(C=CC(=C1)NC(=O)NC2=CC=CC(=C2)CNC(=O)OC3CCOC3)C4=CN=CO4    
Isomeric SMILESCOC1=C(C=CC(=C1)NC(=O)NC2=CC=CC(=C2)CNC(=O)O[C@H]3CCOC3)C4=CN=CO4
CAS NumberCAS 198821-22-6
FormulaC43H44ClFN4O11S3
PubChem Compound IDCID 153241.
TargetEGFR tyrosine kinaseInhibitor[2]
EGFR tyrosine kinaseMultitarget[2]
HER2Inhibitor[2]
HER2Multitarget[2]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022059 To Reference
Ref 2GSK. Product Development Pipeline. February 2009. To Reference



 

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