Therapeutic Targets Database
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TTD Drug ID: DCL000040

Drug Information
NameAMD-070
Synonyms690656-53-2; N'-(1H-Benzo[d]imidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine Trihydrobromide Dihydrate; AMD 070; AMD-070; AMD11070; AMD070; CID10126019; S14-0353; CHEMBL1088913; ST51054666; N-(1H-benzoimidazol-2-ylmethyl)-N-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
CompanyGenzyme
IndicationHIV InfectionDiscontinued in Phase I    
Structure

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InChI1S/C21H27N5/c22-12-3-4-14-26(15-20-24-17-9-1-2-10-18(17)25-20)19-
11-5-7-16-8-6-13-23-21(16)19/h1-2,6,8-10,13,19H,3-5,7,11-12,14-15
,22H2,(H,24,25)
InChIKeyWVLHHLRVNDMIAR-UHFFFAOYSA-N
Canonical SMILESC1CC(C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3    
PubChem Compound IDCID 10126019.
PubChem Substance IDSID 3821053.
ClinicalTrials.govNCT00063804;
TargetC-X-C chemokine receptor type 4Antagonist[1][2]
Ref 1Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):559-65. To Reference
Ref 2Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers. Antimicrob Agents Chemother. 2008 May;52(5):1630-4. Epub 2008 Feb 19. To Reference



 

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