Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000040

Drug Information
Synonyms690656-53-2; N'-(1H-Benzo[d]imidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine Trihydrobromide Dihydrate; AMD 070; AMD-070; AMD11070; AMD070; CID10126019; S14-0353; CHEMBL1088913; ST51054666; N-(1H-benzoimidazol-2-ylmethyl)-N-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
IndicationHIV InfectionDiscontinued in Phase I    

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Canonical SMILESC1CC(C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3    
PubChem Compound IDCID 10126019.
PubChem Substance IDSID 3821053.
TargetC-X-C chemokine receptor type 4Antagonist[1][2]
Ref 1Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):559-65. To Reference
Ref 2Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers. Antimicrob Agents Chemother. 2008 May;52(5):1630-4. Epub 2008 Feb 19. To Reference


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