Therapeutic Targets Database
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TTD Drug ID: DCL000043

Drug Information
NameAMG 076
CompanyAmgen
IndicationObesity
[ICD9: 278   ICD10: E66]
Discontinued in Phase I    
Structure

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InChI1S/C26H33F3N2O2/c1-16-20-15-31(12-10-25(24(32)33)8-3-2-4-9-25)11-
7-17(20)13-22-23(16)19-14-18(26(27,28)29)5-6-21(19)30-22/h5-6,14,
16-17,20,30H,2-4,7-13,15H2,1H3,(H,32,33)/t16-,17-,20-/m1/s1
InChIKeyWAOZNBXSEVIAGX-MBOZVWFJSA-N
Canonical SMILESCC1C2CN(CCC2CC3=C1C4=C(N3)C=CC(=C4)C(F)(F)F)CCC5(CCCCC5)C(=O)O    
Isomeric SMILESC[C@@H]1[C@H]2CN(CC[C@@H]2CC3=C1C4=C(N3)C=CC(=C4)C(F)(F)F)CCC5(CCCCC5)C
(=O)O
PubChem Compound IDCID 10004545.
ChEBI43362;
TargetMelanin-concentrating hormone receptor 1Antagonist[1]
Ref 1Stereoselective synthesis of a MCHr1 antagonist. J Org Chem. 2007 Dec 7;72(25):9648-55. Epub 2007 Nov 13. To Reference



 

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