Therapeutic Targets Database
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TTD Drug ID: DCL000044

Drug Information
NameAMG-517
SynonymsBD-0082; AMG-517; AMG 517; CHEMBL229430
CompanyAmgen
IndicationChronic pathological pain
[ICD9: 338,780   ICD10: R52, G89]
Discontinued in Phase I    
Structure

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InChI1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-
9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27
,28)
InChIKeyYUTIXVXZQIQWGY-UHFFFAOYSA-N
Canonical SMILESCC(=O)NC1=NC2=C(C=CC=C2S1)OC3=NC=NC(=C3)C4=CC=C(C=C4)C(F)(F)F    
Therapeutic ClassAnalgesics
PubChem Compound IDCID 16007367.
PubChem Substance IDSID 24383515.
TargetTrpV1 receptorBlocker[1][2]
Ref 1Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. Epub 2009 Mar 5. To Reference
Ref 2The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov. 2007 May;6(5):357-72. To Reference



 

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