Therapeutic Targets Database
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TTD Drug ID: DCL000048

Drug Information
NameAnacetrapib
SynonymsD08855; 875446-37-0; Anacetrapib; CID 11556427; Anacetrapib (USAN); UNII-P7T269PR6S; MK0859; MK-0859; CID11556427
CompanyMerck
IndicationAtherosclerosis
[ICD9: 414.0, 440   ICD10: I70]
Phase III    [1]
Hyperlipidemia
[ICD9: 272.0-272.4   ICD10: E78]
Phase II    [1]
Structure

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InChI1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28
(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)1
0-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1
InChIKeyMZZLGJHLQGUVPN-HAWMADMCSA-N
Canonical SMILESCC1C(OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=
C4)C(F)(F)F)C(F)(F)F    
Isomeric SMILESC[C@H]1[C@H](OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=
CC(=CC(=C4)C(F)(F)F)C(F)(F)F
CAS NumberCAS 875446-37-0
FormulaC30H25F10NO3
PubChem Compound IDCID 11556427.
PubChem Substance IDSID 16658560.
ClinicalTrials.govNCT00685776;
NCT00977288;
TargetCholesteryl ester transfer proteinInhibitor[2][3][4][5][6]
Cholesteryl ester transfer proteinInhibitor[2][3][4]
Ref 1Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81. To Reference
Ref 2Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. Br J Clin Pharmacol. 2009 May;67(5):520-6. Epub 2009 Feb 4. To Reference
Ref 3Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Apr;31(3):183-227. To Reference
Ref 4The end of the road for CETP inhibitors after torcetrapib? Curr Opin Cardiol. 2009 Jul;24(4):364-71. To Reference
Ref 5Merck. Product Development Pipeline. July 15 2009. To Reference
Ref 6Merck. Report of Merck. 2007. To Reference



 

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