Therapeutic Targets Database
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TTD Drug ID: DCL000059

Drug Information
NameAT9283
CompanyAstex Therape.
IndicationLeukemia, Myeloid
[ICD9: 208.9   ICD10: C91-C95]
Phase I    
Structure

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InChI1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4
-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13,20,25H,2-3,5
-8,11H2,(H2,21,24,27)/b18-17-
InChIKeyVRXXZJLHPWWXIX-ZCXUNETKSA-N
Canonical SMILESC1CC1NC(=O)NC2=CNNC2=C3N=C4C=CC(=CC4=N3)CN5CCOCC5    
Isomeric SMILESC1CC1NC(=O)NC\2=CNN/C2=C\3/N=C4C=CC(=CC4=N3)CN5CCOCC5
Therapeutic ClassAntineoplastic Agents
PubChem Compound IDCID 11696609.
ClinicalTrials.govNCT00522990;
TargetAurora-AInhibitor[1][2]
Aurora-AMultitarget[1][2]
Aurora-BInhibitor[1][2]
Aurora-BMultitarget[1][2]
Ref 1Aurora B kinase inhibition in mitosis: strategies for optimising the use of aurora kinase inhibitors such as AT9283. Cell Cycle. 2009 Jun 15;8(12):1921-9. Epub 2009 Jun 15. To Reference
Ref 2J Med Chem. 2009 Jan 22;52(2):379-88.Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. To Reference



 

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