Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000061

Drug Information
NameAZD3409
CompanyAstraZeneca
IndicationSolid Tumors
[ICD9: 140-199, 210-229   ICD10: C00-C75, C7A, C7B, D10-D36, D3A]
Discontinued in Phase I    
Structure

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InChI1S/C29H39FN4O3S2/c1-19(2)37-28(35)26(12-15-38-4)33-20(3)25-16-23(
8-7-21(25)11-13-30)32-18-24-9-10-27(34-24)39-29(36)22-6-5-14-31-1
7-22/h5-8,14,16-17,19,24,26-27,32-34H,3,9-13,15,18H2,1-2,4H3/t24-
,26-,27-/m0/s1
InChIKeyGIJNHMGFNKZBIR-URORMMCBSA-N
Canonical SMILESCC(C)OC(=O)C(CCSC)NC(=C)C1=C(C=CC(=C1)NCC2CCC(N2)SC(=O)C3=CN=CC=C3)CCF    
Isomeric SMILESCC(C)OC(=O)[C@H](CCSC)NC(=C)C1=C(C=CC(=C1)NC[C@@H]2CC[C@@H](N2)SC(=O)C3=
CN=CC=C3)CCF
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 345915-10-8
PubChem Compound IDCID 56603668.
TargetFarnesyl protein transferaseInhibitor[1][2][3]
Ref 1AZD3409 inhibits the growth of breast cancer cells with intrinsic resistance to the EGFR tyrosine kinase inhibitor gefitinib. Breast Cancer Res Treat. 2007 May;102(3):275-82. Epub 2006 Sep 27. To Reference
Ref 2Radiosensitizing effects of the prenyltransferase inhibitor AZD3409 against RAS mutated cell lines. Cancer Biol Ther. 2006 Sep;5(9):1206-10. Epub 2006 Sep 11. To Reference
Ref 3Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors. Anal Chem. 2006 Apr 15;78(8):2617-22. To Reference



 

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