Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000079

Drug Information
IndicationMyeloid LeukemiaDiscontinued in Phase I    

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Canonical SMILESC1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5    
Therapeutic ClassAntineoplastic Agents
PubChem Compound IDCID 10430360.
TargetStress-activated protein kinase JNK1Inhibitor[1][2]
Ref 1Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89(4):470-84. Epub 2009 Feb 2. To Reference
Ref 2A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis. Kidney Int. 2007 Sep;72(6):698-708. Epub 2007 Jun 27. To Reference


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