Therapeutic Targets Database
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TTD Drug ID: DCL000085

Drug Information
NameCHR-2797
SynonymsCHR-2797; Tosedostat, CHR2797, CHR-2797; BB-76163; 238750-77-1; S1522_Selleck; Tosedostat; Benzeneacetic acid, alpha-(((2R)-2-((1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)amino)-, cyclopentyl ester, (alphaS)-
CompanyChroma Therape.
IndicationMyeloid LeukemiaPhase II    
Solid Tumors
[ICD9: 140-199, 210-229   ICD10: C00-C75, C7A, C7B, D10-D36, D3A]
Phase I completed    
Structure

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InChI1S/C21H30N2O6/c1-13(2)12-16(18(24)20(26)23-28)19(25)22-17(14-8-4-
3-5-9-14)21(27)29-15-10-6-7-11-15/h3-5,8-9,13,15-18,24,28H,6-7,10
-12H2,1-2H3,(H,22,25)(H,23,26)/t16-,17+,18+/m1/s1
InChIKeyFWFGIHPGRQZWIW-SQNIBIBYSA-N
Canonical SMILESCC(C)CC(C(C(=O)NO)O)C(=O)NC(C1=CC=CC=C1)C(=O)OC2CCCC2    
Isomeric SMILESCC(C)C[C@H]([C@@H](C(=O)NO)O)C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC2CCCC2
Therapeutic ClassAntineoplastic Agents
PubChem Compound IDCID 15547703.
PubChem Substance IDSID 50094128.
ClinicalTrials.govNCT00692354;
NCT00780598;
TargetPuromycin-sensitive aminopeptidase (PSA)Inhibitor[1]
Ref 1Cancer Res. 2008 Aug 15;68(16):6669-79.CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. To Reference



 

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