Therapeutic Targets Database
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TTD Drug ID: DCL000087

Drug Information
NameCilansetron
SynonymsCilansetron (USAN/INN); 120635-74-7; DU-123265; D03495; CID6918107; Cilansetron; Calmactin; KC-9946
CompanySolvay Pharma.
IndicationIrritable Bowel Syndrome (IBS), Diarrhea
[ICD9: 564.1, 787.91   ICD10: A09, K58, K59.1]
Phase III, Positive phase III results    [1]
Structure

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InChI1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-
4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3/t1
5-/m1/s1
InChIKeyNCNFDKWULDWJDS-OAHLLOKOSA-N
Canonical SMILESCC1=NC=CN1CC2CCC3=C(C2=O)C4=C5N3CCCC5=CC=C4    
Isomeric SMILESCC1=NC=CN1C[C@H]2CCC3=C(C2=O)C4=C5N3CCCC5=CC=C4
CAS NumberCAS 120635-74-7
PubChem Compound IDCID 6918107.
PubChem Substance IDSID 12014360.
SuperDrug ATC IDA03AE03
A03AE03
Target5-hydroxy-tryptamine 3B receptorAntagonist[2][3]
Ref 1Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. To Reference
Ref 2Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol. 2009 Jul;104(7):1831-43; quiz 1844. Epub 2009 May 26. To Reference
Ref 3Serotonin receptor modulators in the treatment of irritable bowel syndrome. Ther Clin Risk Manag. 2008 Feb;4(1):41-8. To Reference



 

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