Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000101

Drug Information
NameDapagliflozin
SynonymsAKOS005145763; 2-(3-(4-Ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol; Dapagliflozin (INN/USAN); Dapagliflozin; D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-; D08897; BMS-512148; CID9887712; BMS-512148, Dapagliflozin; 461432-26-8; D-Glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-ethoxyphenyl)methyl)phenyl)-, (1S)-; BMS 512148; CHEMBL429910; S1548_Selleck
CompanyAstraZeneca
IndicationDiabetes Mellitus Type 2
[ICD9: 250   ICD10: E11]
Phase III    
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
InChI1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21
-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1
H3/t17-,18-,19+,20-,21+/m1/s1
InChIKeyJVHXJTBJCFBINQ-ADAARDCZSA-N
Canonical SMILESCCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl    
Isomeric SMILESCCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)
O)O)Cl
CAS NumberCAS 461432-26-8
PubChem Compound IDCID 9887712.
PubChem Substance IDSID 14855234.
SuperDrug ATC IDA10BX09
A10BX09
ClinicalTrials.govNCT00528372;
TargetSodium/glucose cotransporter 2Blocker[1][2][3]
Ref 1Dapagliflozin for the treatment of type 2 diabetes. Ann Pharmacother. 2009 Jul;43(7):1286-93. Epub 2009 Jul 7. To Reference
Ref 2A Study of Dapagliflozin in Patients With Type 2 Diabetes on High Doses of Insulin Plus Insulin Sensitizers: Applicability of a Novel Insulin-Independent Treatment. Diabetes Care. 2009 Jun 15. [Epub ahead of print] To Reference
Ref 3Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Mar;31(2):107-46. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543