Therapeutic Targets Database
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TTD Drug ID: DCL000138

Drug Information
NameIsofagomine tartrate
SynonymsNN-42-1007; Plicera; HGT-3410; Isofagomine tartrate; Afegostat tartrate; AT-2101
Trade NamePlicera
CompanyAmicus Therape.
IndicationMetabolic Disease
[ICD9: 270-279   ICD10: E70-E89]
Phase II    
Structure

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InChI1S/C6H13NO3.C4H6O6/c8-3-4-1-7-2-5(9)6(4)10;5-1(3(7)8)2(6)4(9)10/h
4-10H,1-3H2;1-2,5-6H,(H,7,8)(H,9,10)/t4-,5-,6-;1-,2-/m11/s1
InChIKeyULBPPCHRAVUQMC-MUMXBIPUSA-N
Canonical SMILESC1C(C(C(CN1)O)O)CO.C(C(C(=O)O)O)(C(=O)O)O    
Isomeric SMILESC1[C@@H]([C@H]([C@@H](CN1)O)O)CO.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
CAS NumberCAS 957230-65-8
FormulaC10H19NO9
PubChem Compound IDCID 23581846.
PubChem Substance IDSID 46387102.
TargetGlucosylceramidaseInhibitor[1][2]
Ref 1Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. Chembiochem. 2008 Nov 3;9(16):2650-62. To Reference
Ref 2Isofagomine induced stabilization of glucocerebrosidase. Chembiochem. 2008 Nov 3;9(16):2643-9. To Reference



 

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