Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000145

Drug Information
NameKU-0059436
Synonyms4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one; 937799-91-2; AZD2281; KU-0059436; AKOS005145764; Olaparib, KU-0059436, AZD2281, KU0059436, AZD2281; S1060_Selleck; Olaparib; AZD-2281; AZD 2281; EC-000.2324; CHEMBL521686; EN002690; KU-59436; 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one; 763113-22-0; FT-0083489; Acylpiperazine analogue, 47
CompanyAstraZeneca
IndicationGastric Cancer; Breast Cancer; Ovarian Cancer
[ICD9: 140-229, 151, 174, 175, 183   ICD10: C00-C96, C16, C50, C56]
Phase II    
Neoplasm Metastasis; Solid Tumors
[ICD9: 140-199, 140-239, 210-229   ICD10: C00-C75, C00-C96, C7A, C7B, D10-D36, D3A]
Phase I    
Structure

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InChI1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-2
1)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16
H,6-7,9-12,14H2,(H,27,30)
InChIKeyFDLYAMZZIXQODN-UHFFFAOYSA-N
Canonical SMILESC1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 937799-91-2
PubChem Compound IDCID 23725625.
PubChem Substance IDSID 47209066.
ClinicalTrials.govNCT00633269;
NCT01063517;
TargetPoly [ADP-ribose] polymerase 1Inhibitor[1][2][3]
Ref 1High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84. Epub 2008 Oct 29. To Reference
Ref 2Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1188-97.Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential. To Reference
Ref 3J Med Chem. 2008 Oct 23;51(20):6581-91. Epub 2008 Sep 19.4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. To Reference



 

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