Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000169

Drug Information
NameMLN8054
SynonymsCHEMBL259084; CID 11712649; MLN8054; ZZL; Kinome_1204; S1100_Selleck; CID11712649; EC-000.2342; MLN-8054
CompanyMillennium, Takeda
IndicationAdvanced malignanciesTerminated in Phase I    
Solid tumours
[ICD9: 140-199   ICD10: C00-C75, C7A, C7B]
Terminated in Phase I    
Structure

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InChI1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)
28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-
10,12H,11H2,(H,33,34)(H,30,31,32)
InChIKeyHHFBDROWDBDFBR-UHFFFAOYSA-N
Canonical SMILESC1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)
O    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 869363-13-3
FormulaC25H15ClF2N4O2
PubChem Compound IDCID 11712649.
PubChem Substance IDSID 16817521.
ClinicalTrials.govNCT00249301;
NCT00652158;
TargetAurora A kinase Inhibitor[1][2][3]
Aurora-AInhibitor[1][2][3]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference
Ref 2Takeda. Product Development Pipeline. July 31 2009. To Reference
Ref 3MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy. Mol Cell Biol. 2007 Jun;27(12):4513-25. Epub 2007 Apr 16. To Reference



 

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