Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000182

Drug Information
NameNXN-188
CompanyNeurAxon
IndicationMigraine and Cluster Headaches
[ICD9: 339.00, 339.01, 339.02, 346   ICD10: G43, G44.0]
Phase I    
Structure

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InChI1S/C27H36N8O5/c28-21(17-18-7-2-1-3-8-18)26(38)34-16-5-4-10-23(34)
25(37)33-22(9-6-15-31-27(29)30)24(36)32-19-11-13-20(14-12-19)35(3
9)40/h1-3,7-8,11-14,21-23H,4-6,9-10,15-17,28H2,(H,32,36)(H,33,37)
(H4,29,30,31)/t21-,22+,23+/m1/s1
InChIKeyYDMBNDUHUNWWRP-VJBWXMMDSA-N
Canonical SMILESC1CCN(C(C1)C(=O)NC(CCCN=C(N)N)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C
(CC3=CC=CC=C3)N    
Isomeric SMILESC1CCN([C@@H](C1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])
C(=O)[C@@H](CC3=CC=CC=C3)N
PubChem Compound IDCID 123853.
ClinicalTrials.govNCT00877838;
Target5-HT receptorAntagonist[1]
5-HT receptorMultitarget[1]
Nitric oxide synthase, brainInhibitor[1]
Nitric oxide synthase, brainMultitarget[1]
Ref 1NeurAxon Announces Positive Phase 1 Trial Data on NXN-188 for Migraine. NeurAxon, Inc. 2007 To Reference



 

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