Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000191

Drug Information
NameOsanetant
SynonymsN-(1-(3-((R)-1-Benzoyl-3-(3,4-dichlorophenyl)-3-piperidyl)propyl)-4-phenyl-4-piperidyl)-N-methylacetamide; PDSP2_001479; SR-142801; Osanetant [INN]; CHEMBL346178; Acetamide, N-(1-(3-(1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl)propyl)-4-phenyl-4-piperidinyl)-N-methyl-, (R)-; SR-142806; CHEBI:354086; LS-187093; N-(1-(3-((3R)-1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl)propyl)-4-phenyl-4-piperidinyl)-N-methylacetamide; n-(1-{3-[(3r)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl}-4-phenylpiperidin-4-yl)-n-methylacetamide; SB-236984; LS-185126; I06-1312; AC1Q3O5K; PDSP1_001495; CID219077; N-[1-[3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-N-methylacetamide; AR-1J7075; SR-14280; AC1L560J; Osanetant
CompanySanofi-aventis
IndicationDepression
[ICD9: 311   ICD10: F32]
Discontinued    [1]
Schizophrenia, Schizoaffective Disorders
[ICD9: 295, 295.70   ICD10: F20, F25]
Discontinued in Phase IIb    [1]
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
InChI1S/C35H41Cl2N3O2/c1-27(41)38(2)35(29-13-7-4-8-14-29)19-23-39(24-2
0-35)21-9-17-34(30-15-16-31(36)32(37)25-30)18-10-22-40(26-34)33(4
2)28-11-5-3-6-12-28/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3/t34-/m0/
s1
InChIKeyDZOJBGLFWINFBF-UMSFTDKQSA-N
Canonical SMILESCC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)
C5=CC=CC=C5    
Isomeric SMILESCC(=O)N(C)C1(CCN(CC1)CCC[C@@]2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)
Cl)Cl)C5=CC=CC=C5
CAS NumberCAS 160492-56-8
PubChem Compound IDCID 219077.
PubChem Substance IDSID 791618.
TargetNK-3 receptorAntagonist[2][3][4]
Ref 1The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. To Reference
Ref 2Pharmacological characterization of senktide-induced tail whips. Neuropharmacology. 2009 Jun 21. [Epub ahead of print] To Reference
Ref 3The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. Epub 2008 Oct 10. To Reference
Ref 4Augmentation of antipsychotic-induced neurochemical changes by the NK3 receptor antagonist talnetant (SB-223412). Neuropharmacology. 2009 Feb;56(2):342-9. Epub 2008 Sep 18. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543