Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000191

Drug Information
SynonymsN-(1-(3-((R)-1-Benzoyl-3-(3,4-dichlorophenyl)-3-piperidyl)propyl)-4-phenyl-4-piperidyl)-N-methylacetamide; PDSP2_001479; SR-142801; Osanetant [INN]; CHEMBL346178; Acetamide, N-(1-(3-(1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl)propyl)-4-phenyl-4-piperidinyl)-N-methyl-, (R)-; SR-142806; CHEBI:354086; LS-187093; N-(1-(3-((3R)-1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl)propyl)-4-phenyl-4-piperidinyl)-N-methylacetamide; n-(1-{3-[(3r)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl}-4-phenylpiperidin-4-yl)-n-methylacetamide; SB-236984; LS-185126; I06-1312; AC1Q3O5K; PDSP1_001495; CID219077; N-[1-[3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-N-methylacetamide; AR-1J7075; SR-14280; AC1L560J; Osanetant
[ICD9: 311   ICD10: F32]
Discontinued    [1]
Schizophrenia, Schizoaffective Disorders
[ICD9: 295, 295.70   ICD10: F20, F25]
Discontinued in Phase IIb    [1]

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Canonical SMILESCC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)
Isomeric SMILESCC(=O)N(C)C1(CCN(CC1)CCC[C@@]2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)
CAS NumberCAS 160492-56-8
PubChem Compound IDCID 219077.
PubChem Substance IDSID 791618.
TargetNK-3 receptorAntagonist[2][3][4]
Ref 1The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. To Reference
Ref 2Pharmacological characterization of senktide-induced tail whips. Neuropharmacology. 2009 Jun 21. [Epub ahead of print] To Reference
Ref 3The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. Epub 2008 Oct 10. To Reference
Ref 4Augmentation of antipsychotic-induced neurochemical changes by the NK3 receptor antagonist talnetant (SB-223412). Neuropharmacology. 2009 Feb;56(2):342-9. Epub 2008 Sep 18. To Reference


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