Therapeutic Targets Database
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TTD Drug ID: DCL000209

Drug Information
NameR411
SynonymsUNII-XN95730F0N; 86924-16-5; Polycyanine; 828271-96-1; R-411; Ro 27-2441; Valategrast hydrochloride; L-Phenylalanine, N-(2-chloro-6-methylbenzoyl)-4-((2,6-dichlorobenzoyl)amino)-, 2-(diethylamino)ethyl ester, monohydrochloride; Valategrast HCl; Poly B 411; R 411
CompanyRoche
IndicationAsthma
[ICD9: 493   ICD10: J45]
Discontinued in Phase II    
Structure

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InChI1S/C30H32Cl3N3O4.ClH/c1-4-36(5-2)16-17-40-30(39)25(35-28(37)26-19
(3)8-6-9-22(26)31)18-20-12-14-21(15-13-20)34-29(38)27-23(32)10-7-
11-24(27)33;/h6-15,25H,4-5,16-18H2,1-3H3,(H,34,38)(H,35,37);1H
InChIKeyCNNHYZRRGXZIIA-UHFFFAOYSA-N
Canonical SMILESCCN(CC)CCOC(=O)C(CC1=CC=C(C=C1)NC(=O)C2=C(C=CC=C2Cl)Cl)NC(=O)C3=C(C=CC=
C3Cl)C.Cl    
PubChem Compound IDCID 44152734.
PubChem Substance IDSID 3781318.
TargetIntegrin beta-1Antagonist[1][2]
Ref 1Functional performance of silicified microcrystalline cellulose versus microcrystalline cellulose: a case study. Drug Dev Ind Pharm. 2009 Apr 8:1-6. [Epub ahead of print] To Reference
Ref 2Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs. 2008;22(2):85-100. To Reference



 

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