Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000214

Drug Information
SynonymsGSK-462795; CHEMBL203665; Relacatib (USAN/INN); AC1OCFML; 362505-84-8; CID6918602; Relacatib; N-[(2S)-4-methyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopentan-2-yl]-1-benzofuran-2-carboxamide; D06634; SB-462795; Azepan-3-one compound 10
IndicationBone Metastases
[ICD9: 198.5   ICD10: C79.51]
Suspend in Phase II in GSK 2005 Reprot    [1]
[ICD9: 733.0   ICD10: M80-M81]
Suspend in Phase I in GSK 2005 Reprot    [1]

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Canonical SMILESCC1CCC(C(=O)CN1S(=O)(=O)C2=CC=CC=N2)NC(=O)C(CC(C)C)NC(=O)C3=CC4=CC=CC=
Isomeric SMILESC[C@@H]1CC[C@@H](C(=O)CN1S(=O)(=O)C2=CC=CC=N2)NC(=O)[C@H](CC(C)C)NC(=O)
CAS NumberCAS 362505-84-8
PubChem Compound IDCID 6918602.
PubChem Substance IDSID 12015588.
TargetCathepsin KInhibitor[2][3][4]
Ref 1Current and future treatments of bone metastases. Expert Opin Emerg Drugs. 2008 Dec;13(4):609-27. To Reference
Ref 2Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8. Epub 2008 Jan 15.The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. To Reference
Ref 3A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys. Bone. 2007 Jan;40(1):122-31. Epub 2006 Sep 7. To Reference
Ref 4Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors. J Med Chem. 2006 Mar 9;49(5):1597-612. To Reference


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