Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000221

Drug Information
SynonymsTocris-1393; 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide; NCGC00025140-01; Lopac0_000100; CID6604009; CHEMBL10284; SB 222200; 174635-69-9; 4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-(1-phenylpropyl)-, (S)-; S 5192; MLS000862200; C109112; N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-carboxamide; AC1O7G71; NCGC00025140-03; NCGC00025140-04; S5192_SIGMA; CHEBI:107077; (S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide; Lopac-S-5192; NCGC00015956-01; 4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-((1S)-1-phenylpropyl)-; EU-0100100; SMR000326963; SB-222200; MLS001056793; NCGC00025140-02
IndicationSchizophrenia, Schizoaffective Disorders
[ICD9: 295, 295.70   ICD10: F20, F25]

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Canonical SMILESCCC(C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)C    
Isomeric SMILESCC[C@@H](C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)C
CAS NumberCAS 174635-69-9
PubChem Compound IDCID 6604009.
PubChem Substance IDSID 10549616.
TargetNK-3 receptorAntagonist[1][2][3]
Ref 1Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats. Psychopharmacology (Berl). 2009 May;204(1):13-24. Epub 2008 Dec 18. To Reference
Ref 2Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease. Neuropharmacology. 2008 Jun;54(7):1143-52. Epub 2008 Mar 18. To Reference
Ref 3Substance P depolarizes striatal projection neurons and facilitates their glutamatergic inputs. J Physiol. 2008 Apr 15;586(8):2143-55. Epub 2008 Feb 28. To Reference


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