Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000226

Drug Information
NameSCIO-469
CompanyScios
IndicationAcute or Chronic Pain
[ICD9: 338,780   ICD10: R52, G89]
Phase Ib    [1]
Rheumatoid ArthritisPhase IIa completed    [1]
Structure

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InChI1S/C10H14O2.C7H6O3.Bi.H2O/c1-10(2,3)8-6-7(11)4-5-9(8)12;8-6-4-2-1
-3-5(6)7(9)10;;/h4-6,11-12H,1-3H3;1-4,8H,(H,9,10);;1H2/q;;+2;/p-2
InChIKeyQBTOPPPWCFUYHS-UHFFFAOYSA-L
Canonical SMILESCC(C)(C)C1=C(C=CC(=C1)O)O.C1=CC=C(C(=C1)C(=O)[O-])[O-].O.[Bi+2]    
Therapeutic ClassAnalgesics
CAS NumberCAS 750646-72-1
PubChem Compound IDCID 24759807.
ClinicalTrials.govNCT00043732;
NCT00508768;
TargetMAP kinase p38Inhibitor[2][3][4]
Ref 1Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. To Reference
Ref 2Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1461-4. Epub 2009 Jan 14. To Reference
Ref 3p38alpha-selective MAP kinase inhibitor reduces tumor growth in mouse xenograft models of multiple myeloma. Anticancer Res. 2008 Nov-Dec;28(6A):3827-33. To Reference
Ref 4Analgesic effects of p38 kinase inhibitor treatment on bone fracture healing. Pain. 2009 Mar;142(1-2):116-26. Epub 2009 Jan 23. To Reference



 

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