Therapeutic Targets Database
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TTD Drug ID: DCL000245

Drug Information
NameTelcagepant
SynonymsMK0974; N-(6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide; CID11319053; MK-0974; CHEMBL236593; Telcagepant; MK 0974; CID 11169048; Telcagepant (USAN); N7R; D09391; 781649-09-0; C525458; CHEBI:502280
CompanyMerck
IndicationCluster Headaches, Migraine
[ICD9: 339, 339.00, 339.01, 339.02, 346, 784.0   ICD10: G43, G43-G44, G44.0, R51]
Phase III    
Structure

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InChI1S/C26H27F5N6O3/c27-18-4-1-3-17(21(18)28)15-6-7-19(23(38)36(13-15
)14-26(29,30)31)33-24(39)35-11-8-16(9-12-35)37-20-5-2-10-32-22(20
)34-25(37)40/h1-5,10,15-16,19H,6-9,11-14H2,(H,33,39)(H,32,34,40)/
t15-,19-/m1/s1
InChIKeyCGDZXLJGHVKVIE-DNVCBOLYSA-N
Canonical SMILESC1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)
N=CC=C5    
Isomeric SMILESC1C[C@H](C(=O)N(C[C@@H]1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)
N4C5=C(NC4=O)N=CC=C5
CAS NumberCAS 781649-09-0
FormulaC26H27F5N6O3
PubChem Compound IDCID 11319053.
PubChem Substance IDSID 16408359.
ClinicalTrials.govNCT00758836;
TargetCalcitonin gene-related peptide receptorAntagonist[1][2][3]
Ref 1CGRP antagonists: novel concept for treatment of migraine. Med Monatsschr Pharm. 2009 May;32(5):182-5. To Reference
Ref 2Elimination of diastereomer interference to determine Telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jun 1;877(16-17):1634-42. Epub 2009 Apr 8. To Reference
Ref 3A flexible and high throughput liquid chromatography-tandem mass spectrometric assay for the quantitation of telcagepant in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 15;877(14-15):1465-71. Epub 2009 Mar 18. To Reference



 

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