Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000249

Drug Information
NameTLR9 agonist
CompanyDynavax Technol.
IndicationColorectal CancerPhase I    
Structure

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InChI1S/C21H24N2O2.C4H6O6/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(
12-13)19(14)21)15-6-4-5-7-17(15)22-18;5-1(3(7)8)2(6)4(9)10/h4-7,1
0,13,19,22H,3,8-9,11-12H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t13-,19+
,21-;1-,2-/m01/s1
InChIKeyJYBKPXVXYJDIFX-DBOHFVDDSA-N
Canonical SMILESCCC1=CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O    
Isomeric SMILESCCC1=C[C@H]2C[C@]3([C@@H]1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC.[C@@H]([C@H]
(C(=O)O)O)(C(=O)O)O
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 375815-87-5
PubChem Compound IDCID 24796742.
ClinicalTrials.govNCT00780988;
TargetToll-like receptor 9Agonist[1]
Ref 1Signalling pathways leading to IFN-alpha production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications. J Intern Med. 2009 Jan;265(1):43-57. To Reference



 

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