Therapeutic Targets Database
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TTD Drug ID: DCL000255

Drug Information
NameTZP-101
CompanyTranzyme
IndicationIleus, Gastroparesis, Miscellaneous Gastrointestinal Disorders
[ICD9: 530-558, 536.3, 537.2, 560.1, 560.31, 777.1, 777.4   ICD10: K20-K64, K31.5, K31.8, K56.0, K56.3, K56.7, P76.1]
Phase IIb    [1]
Structure

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InChI1S/C30H39FN4O4/c1-19-18-33-27(23-12-13-23)30(38)35(3)20(2)28(36)3
4-25(17-21-10-14-24(31)15-11-21)29(37)32-16-6-8-22-7-4-5-9-26(22)
39-19/h4-5,7,9-11,14-15,19-20,23,25,27,33H,6,8,12-13,16-18H2,1-3H
3,(H,32,37)(H,34,36)/t19-,20-,25-,27+/m1/s1
InChIKeyWGYPAJVJMXQXTR-ABNZCKJZSA-N
Canonical SMILESCC1CNC(C(=O)N(C(C(=O)NC(C(=O)NCCCC2=CC=CC=C2O1)CC3=CC=C(C=C3)F)C)C)C4CC4    
Isomeric SMILESC[C@@H]1CN[C@H](C(=O)N([C@@H](C(=O)N[C@@H](C(=O)NCCCC2=CC=CC=C2O1)CC3=
CC=C(C=C3)F)C)C)C4CC4
PubChem Compound IDCID 11526696.
ClinicalTrials.govNCT00617552;
TargetGrowth hormone secretagogue receptor type 1Agonist[2][3][4]
Ref 1Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26. To Reference
Ref 2Contribution of protein binding to the pharmacokinetics of the ghrelin receptor agonist TZP-101 in healthy volunteers and adults with symptomatic gastroparesis: two randomized, double-blind studies and a binding profile study. Clin Drug Investig. 2009;29(6):409-18. doi: 10.2165/00044011-200929060-00004. To Reference
Ref 3Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis. Aliment Pharmacol Ther. 2009 Jun 1;29(11):1179-87. Epub 2009 Feb 27. To Reference
Ref 4Eur J Pharmacol. 2009 Feb 14;604(1-3):132-7. Epub 2008 Dec 14.Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus. To Reference



 

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