Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000260

Drug Information
SynonymsVX-702; Kinome_3176; EC-000.2363; S6005_Selleck; 6-[carbamoyl-(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)pyridine-3-carboxamide; ST51054128; CHEMBL1090090; I14-1965; CHEBI:719385; CID10341154
CompanyVertex Pharma.
IndicationInflammatory DisordersPhase I    [1]
Rheumatoid Arthritis, Coronary Artery Disease
[ICD9: 410-414, 429.2, 710-719, 714   ICD10: I20-I25, M00-M25, M05-M06]
Phase IIa completed    [1]

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
Canonical SMILESC1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F    
CAS NumberCAS 479543-46-9
PubChem Compound IDCID 10341154.
PubChem Substance IDSID 15352551.
TargetMAP kinase p38Inhibitor[2][3]
Ref 1Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. To Reference
Ref 2Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009 May;60(5):1232-41. To Reference
Ref 3Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome. Curr Opin Investig Drugs. 2006 Nov;7(11):1020-5. To Reference


Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.

Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543