Therapeutic Targets Database
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TTD Drug ID: DCL000260

Drug Information
NameVX-702
SynonymsVX-702; Kinome_3176; EC-000.2363; S6005_Selleck; 6-[carbamoyl-(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)pyridine-3-carboxamide; ST51054128; CHEMBL1090090; I14-1965; CHEBI:719385; CID10341154
CompanyVertex Pharma.
IndicationInflammatory DisordersPhase I    [1]
Rheumatoid Arthritis, Coronary Artery Disease
[ICD9: 410-414, 429.2, 710-719, 714   ICD10: I20-I25, M00-M25, M05-M06]
Phase IIa completed    [1]
Structure

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InChI1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-1
6)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
InChIKeyFYSRKRZDBHOFAY-UHFFFAOYSA-N
Canonical SMILESC1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F    
CAS NumberCAS 479543-46-9
PubChem Compound IDCID 10341154.
PubChem Substance IDSID 15352551.
ClinicalTrials.govNCT00395577;
TargetMAP kinase p38Inhibitor[2][3]
Ref 1Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. To Reference
Ref 2Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009 May;60(5):1232-41. To Reference
Ref 3Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome. Curr Opin Investig Drugs. 2006 Nov;7(11):1020-5. To Reference



 

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