TTD Drug ID: DCL000265

Drug Information
Name	XL880
Synonyms	CHEMBL1230609; S1111_Selleck; XL880; GSK1363089; 88Z; GSK 1363089; EC-000.2326; 937176-80-2; XL 880; GSK 089; GSK1363089, GSK089, foretinib, EXEL-2880, XL880
Company	Exelixis / GlaxoSmithKline
Indication	Gastric Cancer, Renal Cell Carcinoma, Squamous Cell Cancer of the Head and Neck [ICD9: 140-229, 151, 189   ICD10: C00-C96, C16, C64]			Phase II    [1]
	Solid Tumors [ICD9: 140-199, 210-229   ICD10: C00-C75, C7A, C7B, D10-D36, D3A]			Phase I    [1]
Structure	Click to save drug structure in 3D MOL format Click to save drug structure in 2D MOL format
InChI	1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44 -18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-1 1-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2, 1H3,(H,38,41)(H,39,42)
InChIKey	CXQHYVUVSFXTMY-UHFFFAOYSA-N
Canonical SMILES	COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6= CC=C(C=C6)F)F
Therapeutic Class	Antineoplastic Agents
PubChem Compound ID	CID 42642645.
PubChem Substance ID	SID 81082087.
ClinicalTrials.gov	NCT00725712;
	NCT00742131;
Target	C-Met receptor tyrosine kinase			Inhibitor	[2][3][4][1][5]
	C-Met receptor tyrosine kinase			Multitarget	[2][3][4][1][5]
	Vascular endothelial growth factor receptor 2			Inhibitor	[2][3][4][1][5]
	Vascular endothelial growth factor receptor 2			Multitarget	[2][3][4][1][5]
Ref 1	2011 Pipeline of Exelixis. To Reference
Ref 2	Pipeline of EXELIXIS. EXELIXIS. 2009 To Reference
Ref 3	MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20932-7. Epub 2007 Dec 18. To Reference
Ref 4	Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Mar;29(2):153-73. To Reference
Ref 5	GSK. Product Development Pipeline. February 2009. To Reference

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