Therapeutic Targets Database
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TTD Drug ID: DCL000273

Drug Information
NameLonapalene
SynonymsLonapalenum; CHEBI:153018; Lonapaleno [Spanish]; CHEMBL36648; Lonapalene (USAN); RS-43179; CID56237; Lonapalenum [Latin]; LONAPALENE; RS 43179; D04770; 6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate; AC1L1KN9; Lonapaleno; (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate; 91431-42-4
CompanyBristol-Myers Squibb
IndicationPsoriasis
[ICD9: 696   ICD10: L40]
Discotinued in Phase III    
Structure

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InChI1S/C16H15ClO6/c1-8(18)22-13-11-6-5-10(17)7-12(11)14(23-9(2)19)16(
21-4)15(13)20-3/h5-7H,1-4H3
InChIKeyIFWMVQUGSGWCRP-UHFFFAOYSA-N
Canonical SMILESCC(=O)OC1=C(C(=C(C2=C1C=CC(=C2)Cl)OC(=O)C)OC)OC    
CAS NumberCAS 91431-42-4
PubChem Compound IDCID 56237.
PubChem Substance IDSID 193575.
TargetArachidonate 5-lipoxygenaseInhibitor[1][2]
Ref 1Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45. To Reference
Ref 2Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis. J Invest Dermatol. 1990 Jul;95(1):50-4. To Reference



 

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