Therapeutic Targets Database
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TTD Drug ID: DCL000286

Drug Information
NamePeramivir
SynonymsCyclopentanecarboxylic acid, 3-((1S)-1-(acetylamino)-2-ethylbutyl)-4-((aminoiminomethyl)amino)-2-hydroxy-, (1S,2S,3R,4R)-; S-021812; AC1L4BWX; CID151164; CID154234; BCX1812; RWJ270201; 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID; (1S,2S,3S,4R)-3-(1-acetamido-2-ethylbutyl)-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid; UNII-QW7Y7ZR15U; BCX 1812; Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-, (1S,2S,3R,4R)-; 330600-85-6; CHEBI:292932; RWJ 270201; RWJ-270201; Cyclopentanecarboxylic acid, 3-((1R)-1-(acetylamino)-2-ethylbutyl)-4-((aminoiminomethyl)amino)-2-hydroxy-, (1R,2R,3S,4S)-rel-; (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid; Rapiacta; CHEBI:41095; Peramivir; 1A5BB290; 229614-56-6; PeramiFlu; CHEMBL139367; CHEMBL332608; 3-(1'-acetylamino-2'-ethyl)butyl-4-((aminoimino)methyl)amino-2-hydroxycyclopentane-1-carboxylic acid; BCZ; 229614-55-5; AC1L45SI; BCX-1812
CompanyBioCryst Pharmaceuticals
IndicationInfluenza virus infection
[ICD9: 487   ICD10: J10, J11]
Phase III    [1]
Structure

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InChI1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11
)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19
)/t9-,10+,11+,12?,13+/m0/s1
InChIKeyXRQDFNLINLXZLB-GKWMMFDUSA-N
Canonical SMILESCCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C    
Isomeric SMILESCCC(CC)C([C@H]1[C@@H](C[C@@H]([C@H]1O)C(=O)O)N=C(N)N)NC(=O)C
CAS NumberCAS 229614-55-5
FormulaC15H28N4O4
PubChem Compound IDCID 151164.
PubChem Substance IDSID 728706.
ClinicalTrials.govNCT00957996;
TargetNeuraminidaseInhibitor[2][3]
Ref 1Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416. To Reference
Ref 2Developing new antiviral agents for influenza treatment: what does the future hold? Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13. To Reference
Ref 3Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102. Epub 2008 Feb 4. To Reference



 

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