Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000290

Drug Information
NameTOP-53
Synonyms(5R,5aR,8aR,9S)-9-[2-[2-dimethylaminoethyl(methyl)amino]ethyl]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-6-one dihydrochloride; CID6918225; TOP-53; AC1OCF6H; Top 53
CompanyTaiho Pharmaceutical Co., Ltd.
IndicationLung tumors and lung metastatic tumors
[ICD9: 162   ICD10: C33, C34]
Phase I    
Structure

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InChI1S/C28H36N2O7.2ClH/c1-29(2)8-9-30(3)7-6-17-18-12-21-22(37-15-36-2
1)13-19(18)25(26-20(17)14-35-28(26)32)16-10-23(33-4)27(31)24(11-1
6)34-5;;/h10-13,17,20,25-26,31H,6-9,14-15H2,1-5H3;2*1H/t17-,20-,2
5-,26+;;/m1../s1
InChIKeyAOGFGBUUQUKBHV-LICKGGAWSA-N
Canonical SMILESCN(C)CCN(C)CCC1C2COC(=O)C2C(C3=CC4=C(C=C13)OCO4)C5=CC(=C(C(=C5)OC)O)OC.
Cl.Cl    
Isomeric SMILESCN(C)CCN(C)CC[C@H]1[C@H]2COC(=O)[C@@H]2[C@@H](C3=CC4=C(C=C13)OCO4)C5=CC
(=C(C(=C5)OC)O)OC.Cl.Cl
CAS NumberCAS 147238-98-0
PubChem Compound IDCID 6918225.
PubChem Substance IDSID 12014725.
TargetDNA topoisomerase IIInhibitor[1]
Ref 1DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action. Biochemistry. 2001 Jan 23;40(3):712-8. To Reference



 

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